Advances in Dermatology and Allergology
eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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Letter to the Editor

Ibuprofen-induced multiple fixed drug eruption in a 3-year-old child confirmed by patch testing

Maciej Szczukocki
1
,
Żaneta Chodurska
1
,
Paulina Kasprzak-Kaliniak
2

  1. Collegium Medicum, Jan Kochanowski University, Kielce, Poland
  2. 1st Paediatric Clinic, Provincial Hospital, Kielce, Poland
Adv Dermatol Allergol
DOI: https://doi.org/10.5114/ada.2026.159165
Online publish date: 2026/02/13
Article file
- Ibuprofen.pdf  [0.17 MB]
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1. Tavares Almeida F, Caldas R, André Oliveira Á, et al. Generalised bullous fixed drug eruption caused by ibuprofen: a case report. Contact Dermatitis 2019; 80: 238-9.
2. Bhanja DB, Sil A, Panigrahi A, Chakraborty S. Ibuprofen-induced generalised bullous fixed drug eruption. Postgrad Med J 2020; 96: 706-7.
3. Tempark T, John S, Rerknimitr P, et al. Drug-induced severe cutaneous adverse reactions: insights into clinical presentation, immunopathogenesis, diagnostic methods, treatment, and pharmacogenomics. Front Pharmacol 2022; 13: 832048.
4. Mizukawa Y, Yamazaki Y, Shiohara T. In vivo dynamics of intraepidermal CD8+ T cells and CD4+ T cells during the evolution of fixed drug eruption. Br J Dermatol 2008; 158: 1230-8.
5. Shiohara T, Mizukawa Y, Teraki Y. Pathophysiology of fixed drug eruption: the role of skin-resident T cells. Curr Opin Allergy Clin Immunol 2002; 2: 317-23.
6. Shiohara T. Fixed drug eruption: pathogenesis and diagnostic tests. Curr Opin Allergy Clin Immunol 2009; 9: 316-21.
7. Andrade P, Brinca A, Gonçalo M. Patch testing in fixed drug eruptions: a 20-year review. Contact Dermatitis 2011; 65: 195-201.
8. Ben Fadhel N, Chaabane A, Ammar H, et al. Clinical features, culprit drugs, and allergology workup in 41 cases of fixed drug eruption. Contact Dermatitis 2019; 81: 336-40.
9. Anderson HJ, Lee JB. A review of fixed drug eruption with a special focus on generalized bullous fixed drug eruption. Medicina 2021; 57: 925.
Copyright: © 2026 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.

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