Polish Journal of Pathology
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ISSN: 1233-9687
Polish Journal of Pathology
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2/2025
vol. 76
 
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Original paper

Identification of metabolism regulators as diagnostic markers for ulcerative colitis and their correlation with immune infiltration

Qilong Duan
1
,
Peng Liu
1
,
Hualei Chen
2
,
Yuanyuan Ding
2
,
Xiaoming Xu
2

  1. Shandong Medical College, Jinan, China
  2. Department of Gastroenterology, Jining No. 1 People’s Hospital, Jining, China
Pol J Pathol 2025; 76 (2): 110-119
Online publish date: 2025/09/22
Article file
- PJP-03200.pdf  [3.39 MB]
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1. Gros B, Kaplan GG. Ulcerative Colitis in Adults: A Review. JAMA 2023; 330: 951-965.
2. Syed S, Boland BS, Bourke LT, et al. Challenges in IBD Re­search 2024: Precision Medicine. Inflamm Bowel Dis 2024; 30 (Suppl 2): S39-S54.
3. Le Berre C, Honap S, Peyrin-Biroulet L. Ulcerative colitis. Lan­cet 2023; 402: 571-584.
4. Honap S, Jairath V, Danese S, Peyrin-Biroulet L. Navigating the complexities of drug development for inflammatory bowel disease. Nat Rev Drug Discov 2024; 23: 546-562.
5. Neurath MF, Vieth M. Different levels of healing in inflamma­tory bowel diseases: mucosal, histological, transmural, barrier and complete healing. Gut 2023; 72: 2164-2183.
6. Honap S, Jairath V, Sands BE, Dulai PS, Danese S, Peyrin-Bir­oulet L. Acute severe ulcerative colitis trials: the past, the pres­ent and the future. Gut 2024; 73: 1763-1773.
7. Fang X, Ardehali H, Min J, Wang F. The molecular and meta­bolic landscape of iron and ferroptosis in cardiovascular disease. Nat Rev Cardiol 2023; 20: 7-23.
8. Faqerah N, Walker D, Gerasimidis K. Review article: The com­plex interplay between diet and Escherichia coli in inflammatory bowel disease. Aliment Pharmacol Ther 2023; 58: 984-1004.
9. Guo J, Li L, Cai Y, Kang Y. The development of probiotics and prebiotics therapy to ulcerative colitis: a therapy that has gained considerable momentum. Cell Commun Signal 2024; 22: 268.
10. Yang Y, Xiao G, Cheng P, Zeng J, Liu Y. Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflam­mation in Humans and Animals. Molecules 2023; 28: 6811.
11. Zhang X, Zhang B, Peng B, et al. Different Dose of Sucrose Consumption Divergently Influences Gut Microbiota and PPAR-γ/MAPK/NF-κB Pathway in DSS-Induced Colitis Mice. Nutrients 2022; 14: 2765.
12. Long D, Mao C, Huang Y, Xu Y, Zhu Y. Ferroptosis in ulcer­ative colitis: Potential mechanisms and promising therapeutic targets. Biomed Pharmacother 2024; 175: 116722.
13. Peng S, Shen L, Yu X, et al. The role of Nrf2 in the pathogen­esis and treatment of ulcerative colitis. Front Immunol 2023; 14: 1200111.
14. Li J, Luo X, Shiu PH, et al. Protective effects of Amauroderma rugosum on dextran sulfate sodium-induced ulcerative colitis through the regulation of macrophage polarization and sup­pression of oxidative stress. Biomed Pharmacother 2024; 176: 116901.
15. Bourgonje AR, Kloska D, Grochot-Przeczek A, Feelisch M, Cuadrado A, van Goor H Personalized redox medicine in in­flammatory bowel diseases: an emerging role for HIF-1alpha and NRF2 as therapeutic targets. Redox Biol 2023; 60: 102603.
16. He N, Chen K, Yu S, et al. Stachyose Exerts Anticolitis Efficacy by Re-balancing Treg/Th17 and Activating the Butyrate-De­rived PPARgamma Signaling Pathway. J Agric Food Chem 2024; 72: 12171-12183.
17. Wang Y, Li M, Zha A. mTOR promotes an inflammatory re­sponse through the HIF1 signaling pathway in ulcerative coli­tis. Int Immunopharmacol 2024; 134: 112217.
18. Riviere P, Li Wai Suen C, Chaparro M, De Cruz P, Spinelli A, Laharie D. Acute severe ulcerative colitis management: un­answered questions and latest insights. Lancet Gastroenterol Hepatol 2024; 9: 251-262.
19. Thorp EB, Karlstaedt A. Intersection of Immunology and Metab­olism in Myocardial Disease. Circ Res 2024; 134: 1824-1840.
20. Wang X, Zhang C, Zhao G, Yang K, Tao L. Obesity and lipid metabolism in the development of osteoporosis (Review). Int J Mol Med 2024; 54: 61.
21. Dankar R, Wehbi J, Refaat MM. Tailoring Treatment in Cardi­ovascular Diseases: The Role of Targeted Therapies. Pharma­ceutics 2024; 16: 461.
22. Yamaji T, Hanada K. Sphingolipid metabolism and interorga­nellar transport: localization of sphingolipid enzymes and lipid transfer proteins. Traffic 2015; 16: 101-122.
23. Bayoumy AB, Mulder CJJ, Ansari AR, et al. Uphill battle: In­novation of thiopurine therapy in global inflammatory bowel disease care. Indian J Gastroenterol 2024; 43: 36-47.
24. Shi F, Gao YS, Han SM, et al. Allulose mitigates chronic enteri­tis by reducing mitochondria dysfunction via regulating cathep­sin B production. Int Immunopharmacol 2024; 129: 111645.
25. Ge W, Yue M, Lin R, et al. PLA2G2A(+) cancer-associated fi­broblasts mediate pancreatic cancer immune escape via imped­ing antitumor immune response of CD8(+) cytotoxic T cells. Cancer Lett 2023; 558: 216095.
26. Huang X, Yang X, Zhang M, et al. SELENOI Functions as a Key Modulator of Ferroptosis Pathway in Colitis and Colorec­tal Cancer. Adv Sci (Weinh) 2024; 2024: e2404073.
27. Sasidharan K, Caddeo A, Jamialahmadi O, et al. IL32 down­regulation lowers triglycerides and type I collagen in di-line­age human primary liver organoids. Cell Rep Med 2024; 5: 101352.
28. Hatori S, Sakamaki K, Yokohori T, et al. Clinical Significance of PLA2G2A Expression in Gastric Cancer Patients who Re­ceive Gastrectomy and Adjuvant S-1. Anticancer Res 2021; 41: 3583-3588.
29. Fijneman RJ, Cormier RT. The roles of sPLA2-IIA (Pla2g2a) in cancer of the small and large intestine. Front Biosci 2008; 13: 4144-4174.
30. Ding X, Yan F, Wang W, Qin J, Luo L. Integration of tran­scriptomics and metabolomics identify biomarkers of aberrant lipid metabolism in ulcerative colitis. Int Immunopharmacol 2024; 131: 111865.
31. Escudero-Hernández C, van Beelen Granlund A, Bruland T, et al. Transcriptomic Profiling of Collagenous Colitis Identifies Hallmarks of Nondestructive Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol 2021; 12: 665-687.
32. Court MH, Hazarika S, Krishnaswamy S, Finel M, Williams JA. Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction. Mol Phar­macol 2008; 74: 744-754.
33. Wu H, Zhong W, Zhang R, et al. G-quadruplex-enhanced circular single-stranded DNA (G4-CSSD) adsorption of miR­NA to inhibit colon cancer progression. Cancer Med 2023; 12: 9774-9787.
34. Yang X, Li P, Zhuang J, et al. Identification of Molecular Tar­gets of Bile Acids Acting on Colorectal Cancer and Their Cor­relation with Immunity. Dig Dis Sci 2024; 69: 123-134.
35. Low END, Mokhtar NM, Wong Z, Raja Ali RA. Colonic Mu­cosal Transcriptomic Changes in Patients with Long-Duration Ulcerative Colitis Revealed Colitis-Associated Cancer Path­ways. J Crohns Colitis 2019; 13: 755-763.
36. Wu X, Liu P, Wang Q, Sun L, Wang Y. A prognostic model established using bile acid genes to predict the immunity and survival of patients with gastrointestinal cancer. Environ Toxi­col. 2024. doi: 10.1002/tox.24287.
37. Szuber N, Orazi A, Tefferi A. Chronic neutrophilic leukemia and atypical chronic myeloid leukemia: 2024 update on diag­nosis, genetics, risk stratification, and management. Am J He­matol 2024; 99: 1360-1387.
38. Lang W, Luo Y, Wang L, et al. The der(1;7)(q10;p10) defin­ing a distinct profile from -7/del(7q) in myelodysplastic syn­dromes: A systematic review and meta-analysis. Cancer Med 2024; 13: e6890.
39. Chen W, Xu Z, Jiang J, et al. Identification of LPCAT1 as a key biomarker for Crohn's disease based on bioinformatics and machine learnings and experimental verification. Gene. 2024; 920: 148519.
40. Hu Y, Tang J, Xie Y, et al. Gegen Qinlian decoction amelio­rates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammas­ome activation and reshaping gut microbiota. J Ethnopharma­col 2024; 328: 117956.
41. Wang S, Su W, Wu X, Dong W. Restoring Treg/Th17 cell balance in ulcerative colitis through HRas silencing and MAPK pathway inhibition. Int Immunopharmacol 2024; 130: 111608.
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