eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
1/2020
vol. 71
 
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abstract:
Original paper

Image analysis discloses differences in nuclear parameters between ERG+ and ERG– prostatic carcinomas

Krzysztof Okoń
1
,
Grzegorz Dyduch
1
,
Magdalena B. Białas
1
,
Katarzyna Milian-Ciesielska
1
,
Joanna Szpor
1
,
Iga Leszczyńska
1
,
Katarzyna Tyrak
2
,
Tomasz Szopiński
3
,
Piotr Chłosta
4

1.
Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland
2.
2nd Department of Internal Medicine after Professor Andrzej Szczeklik, Jagiellonian University Medical College, Krakow, Poland
3.
Mazovia Hospital, Warsaw, Poland
4.
Department of Urology, Jagiellonian University Medical College, Krakow, Poland
Pol J Pathol 2020; 71 (1): 20-29
Online publish date: 2020/05/20
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Prostatic carcinoma (PC) is the most frequent urologic cancer and one of the most frequent cancers in males; it is a heterogeneous disease, in terms of molecular features, morphology and prognosis. About half of cases depends on TMPRSS2-ETS translocation which leads to a production of ERG transcription factor. ERG+ and ERG– cancers seem to differ in a number of features, which could lead to an altered nuclear structure; the aim of the study was to test this hypothesis. The material consisted of total 39 PC cases, representing ERG+ and ERG–, as well as Gleason pattern 3 and 4. Filtering by color deconvolution and automatic segmentation were used, and the properly detected nuclei were manually selected. From each case fifty nuclei were obtained; then geometric features and texture parameters were assessed. The analysis of the collected data showed differences both between ERG+/ERG– and Gleason pattern 3 and 4 cases in most of the features analyzed. Our results suggest that indeed the ERG status, thus likely TMPRSS2-ETS translocation, has an impact on morphology of nuclei in PC, and their differences are evident enough to be detectable by image analysis.
keywords:

male, neoplasm grading, TMPRSS2 protein, human, prostatic neoplasms, urologic neoplasms

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