eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
5/2019
vol. 36
 
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abstract:
Review paper

Immunometabolic disorders in the pathogenesis of systemic lupus erythematosus

Kamila Tokarska
,
Ireneusz Majsterek
,
Magda Cuchra
,
Anna Woźniacka

Adv Dermatol Allergol 2019; XXXVI (5): 513-518
Online publish date: 2019/11/12
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Systemic lupus erythematosus is a chronic autoimmune disease connected with complex and unclear disorders of the immune system, which causes inflammation of body tissues and internal organs. It leads to the formation of anti-nuclear antibodies (ANA) and immune complexes. Numerous immune system disorders and dysfunctions in the biochemical processes can occur in the course of the disease, and a wide range of abnormalities associated with cellular respiratory processes and mitochondrial function have been documented. The following paper presents the current understanding of the contribution of these disorders to the pathogenesis of lupus.
keywords:

lupus, mitochondrial dysfunction, necrosis, mtDNA

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