ISSN: 2451-0629
Archives of Medical Science - Atherosclerotic Diseases
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Official journal of the International Lipid Expert Panel (ILEP)
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1/2021
vol. 6
 
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abstract:
Clinical research

Implications of advanced oxidation protein products and vitamin E in atherosclerosis progression

Leila Azouaou Toualbi
1, 2
,
Adnane Mounir
3
,
Ballouti Wafa
4
,
Arab Medina
5
,
Khelfi Abderrezak
6
,
Toualbi Chahine
7
,
Chader Henni
8
,
Bennoui Abdelghani
1
,
Seba Atmane
1

1.
Hospital CHU Parnet Universite Algiers, Algeria
2.
Department of Nephrology, Parnet Hospital, Faculty of Medicine Algiers, Algeria
3.
Department of Biomedicine, Institute of Veterinary Sciences, University of Tiaret, Tiaret, Algeria
4.
Department of Biochemistry, Hospital of Parnet, Faculty of Medicine Algiers, Algeria
5.
Department of Biochemistry, Hospital of CPMC, Faculty of Pharmacy, Algiers, Algeria
6.
Department of Toxicology, Hospital of Bab el oued, Faculty of Pharmacy Algiers, Algeria
7.
Department of Orthopedic Surgery, Hospital of Bejaia, Faculty of Medicine, Bejaia, Algeria
8.
Department of Pharmacology, Pastor Institute, Faculty of Pharmacy, Algiers, Algeria
Arch Med Sci Atheroscler Dis 2021; 6: e135–e144
Online publish date: 2021/06/30
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Introduction
Advanced oxidation protein products (AOPP) are considered as markers of oxidative stress and inflammation, and highly predictive of atherosclerosis. Vitamin E (Vit-E) is a powerful antioxidant, but no consensus on its effectiveness at the level of AOPP or the process of atherosclerosis has been made. Hence this was the aim of the present study.

Material and methods
A longitudinal study was conducted on 205 patients with chronic kidney disease (CKD) and 40 controls. The correlations between AOPP and glomerular filtration rate (GFR) and different biological markers were analyzed. Supra-aortic trunk echo-Doppler was conducted to assess the correlation of AOPP with intima-media thickness. The effects of Vit-E treatment on AOPP levels and atherosclerosis progression were also investigated.

Results
AOPP levels increased in parallel to the alteration of renal functions in CKD patients, compared to the control group (p < 0.05). The mean value of AOPP increased concomitantly with the intima-media thickness (p < 0.05). Furthermore, AOPP mean value was higher in patients with atherosclerotic plaques (p < 0.05) compared to those without plaques. Vit-E treatment stabilized the levels of AOPP but had no effect on the atherosclerotic progression.

Conclusions
AOPP were proved to be effective markers of oxidative stress and their high levels help to predict the progression of atherosclerosis. As a powerful antioxidant, Vit-E stabilized the AOPP levels.

keywords:

advanced oxidation protein products, chronic kidney disease, inflammation, atherosclerosis, vitamin E

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