eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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1/2017
vol. 13
 
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abstract:
State of the art paper

Infusional high-density lipoproteins therapies as a novel strategy for treating atherosclerosis

Belinda A. Di Bartolo, Nisha Schwarz, Jordan Andrews, Stephen J. Nicholls

Arch Med Sci 2017; 13, 1: 210–214
Online publish date: 2016/06/30
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High-density lipoproteins (HDL) have received considerable interest as a target for the development of novel anti-atherosclerotic agents beyond conventional approaches to lipid lowering. While a number of approaches have focused on modifying remodeling and expression pathways implicated in the regulation of HDL levels, an additional approach involves simply infusions of delipidated HDL. Several groups have advanced HDL infusions to clinical development with intriguing signs suggesting potentially favorable impacts at the level of the artery wall. The findings of early studies of infusional HDL therapies will be reviewed.
keywords:

high density lipoprotein, risk factors, lipids, atherosclerosis, clinical trials, imaging

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