eISSN: 2299-0054
ISSN: 1895-4588
Videosurgery and Other Miniinvasive Techniques
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4/2021
vol. 16
 
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abstract:
Original paper

Insertion of I-125 seed-loaded stent for inoperable hilar cholangiocarcinoma

Fu-Lei Gao
1, 2
,
Yong Wang
3
,
Jian Lu
3
,
Guang-Yu Zhu
3
,
Xiang-Zhong Huang
2
,
Dong-Qing Ren
2
,
Jin-He Guo
1, 3

1.
Nanjing Medical University, Nanjing, China
2.
Department of Interventional Radiology, Affiliated Jiangyin Hospital of Medical College of Southeast University, Jiangyin, China
3.
Centre of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China
Videosurgery Miniinv 2021; 16 (4): 678–685
Online publish date: 2021/04/20
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Introduction
Stent insertion is the most frequently used option to treat malignant biliary obstruction (MBO) patients. Hilar cholangiocarcinoma (HCCA) is the most common disease that causes hilar MBO.

Aim
To assess the clinical efficacy and long-term outcomes of I-125 seed-loaded stent (ISS) insertion for HCCA patients.

Material and methods
Consecutive patients with HCCA underwent either normal stent (NS) or ISS insertion between January 2017 and December 2019. The baseline and treatment data of these two groups were compared.

Results
During the period, a total of 93 patients with inoperable HCCA were divided into either NS (n = 48) or ISS (n = 45) insertion groups at our centre. Technical success rates of the NS and ISS insertion were 91.7% and 95.6%, respectively (p = 0.733). Clinical success rates were 93.2% and 100% in the NS and ISS groups, respectively (p = 0.24). Stent dysfunction was observed in 11 and 8 patients in the NS and ISS groups, respectively (p = 0.47). The median stent patency was 143 days and 208 days in the NS and ISS groups, respectively (p < 0.001). All patients died in the follow-up period, with median survival duration of 178 days and 220 days in the NS and ISS groups, respectively (p < 0.001). ISS insertion was the only predictor of longer patency (p = 0.002) and survival (p = 0.01).

Conclusions
ISS insertion might achieve longer patency and overall survival in patients with inoperable HCCA as compared with NS insertion.

keywords:

stent, I-125, hilar cholangiocarcinoma, patency, survival

  
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