eISSN: 1731-2531
ISSN: 1642-5758
Anaesthesiology Intensive Therapy
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2/2021
vol. 53
 
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abstract:
Special paper

Invitation to participate in a multi-center study for validation of cerebral computed tomography angiography and computed tomography perfusion in the determination of cerebral circulatory arrest during brain death/death by neurological criteria diagnosis procedure in paediatric population below 12 years of age

Romuald Bohatyrewicz
1
,
Joanna Sołek-Pastuszka
1
,
Wojciech Walas
2
,
Katarzyna Sznajder
3
,
Andrzej Falba
3
,
Katarzyna Chamier-Ciemińska
4
,
Wojciech Poncyljusz
4
,
Wojciech Dąbrowski
5
,
Beata Rybojad
6
,
Magdalena Woźniak
7
,
Joanna Wojczal
8
,
Piotr Luchowski
8
,
Marzena Zielińska
9
,
Maciej Guziński
10
,
Katarzyna Sierakowska
11
,
Tamara Kołakowska
12
,
Zbigniew Serafin
13
,
Alicja Bartkowska-Śniatkowska
14
,
Katarzyna Jończyk-Potoczna
15
,
Krzysztof Kobylarz
16
,
Elżbieta Byrska-Maciejasz
16
,
Łukasz Wyrobek
17
,
Andrzej Piotrowski
18
,
Elżbieta Jurkiewicz
19
,
Andrzej Kościesza
19
,
Marek Migdał
20
,
Mariola Tałałaj
21
,
Piotr Jakubów
21
,
Jacek Robert Janica
22
,
Izabela Pągowska-Klimek
23
,
Michał Brzewski
24
,
Paweł Jurszewicz
25
,
Maria Dziejowska
26
,
Elżbieta Milewicz-Podgórska
27
,
Monika Bekiesinska-Figatowska
28
,
Edyta Szurowska
29
,
Radoslaw Owczuk
30
,
Krzysztof Kusza
31
,
Marcin Sawicki
4

1.
Department of Anesthesiology and Intensive Therapy, Pomeranian Medical University, Szczecin, Poland
2.
Pediatric and Neonatal Intensive Care Unit, University Hospital in Opole, Institute of Medical Science, University of Opole, Poland
3.
Department of Diagnostic Imaging, University Hospital in Opole, Institute of Medical Science, University of Opole, Poland
4.
Department of Diagnostic Imaging and Interventional Radiology, Pomeranian Medical University, Szczecin, Poland
5.
Department of Anesthesiology and Intensive Care, University of Lublin, Poland
6.
Department of Paediatric Anaesthesiology and Intensive Care, Paediatric University Hospital in Lublin, Poland
7.
Department of Paediatric Radiology, University Hospital in Lublin, Poland
8.
Department of Neurology, Medical University of Lublin, Poland
9.
Department of Anesthesiology and Intensive Therapy, Wroclaw Medical University, Poland
10.
Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland
11.
Department of Anesthesiology and Intensive Therapy, Medical University in Bydgoszcz, Poland
12.
Clinical Unit of Paediatric Anaesthesiology and Intensive Therapy, Antoni Jurasz University Hospital No. 1 in Bydgoszcz, Poland
13.
Department of Radiology and Diagnostic Imaging, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Poland
14.
Department of Pediatric Anesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland
15.
Department of Pediatric Radiology, Poznan University of Medical Sciences, Poznan, Poland
16.
Department of Pediatric Anesthesiology and Intensive Care, University Children’s Hospital, Krakow, Poland
17.
Department of Radiology, University Children’s Hospital, Krakow, Poland
18.
Department of Anesthesia and Intensive Care, The Children’s Memorial Health Institute, Warsaw, Poland
19.
Department of Diagnostic Imaging, The Children’s Memorial Health Institute, Warsaw, Poland
20.
The Children’s Memorial Health Institute, Warsaw, Poland
21.
Department of Anaesthesiology and Intensive Care with Postoperative Subunit, Pediatric University Hospital in Bialystok, Poland
22.
Department of Paediatric Radiology, Medical University of Bialystok, Poland
23.
Department of Pediatric Anaesthesiology and Intensive Therapy, Paediatric University Hospital, Warsaw, Poland
24.
Department of Paediatric Radiology, Medical University in Warsaw, Poland
25.
Department of Pediatric Anesthesiology and Intensive Therapy, Independent Public Pediatric Hospital in Warsaw, Poland
26.
Department of Intensive Therapy and Anesthesiology, Regional Specialized Children’s Hospital in Olsztyn, Poland
27.
Department of Radiology, Regional Specialized Children’s Hospital in Olsztyn, Poland
28.
Department of Diagnostic Imaging, Institute of Mother and Child, Warsaw, Poland
29.
2nd Department of Radiology, Medical University of Gdansk, Poland
30.
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Medical University of Gdansk, Poland
31.
Department of Anaesthesiology and Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland
Anaesthesiol Intensive Ther 2021; 53, 2: 97–102
Online publish date: 2021/06/21
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In recent years commensal microorganisms are not just “passive occupants”, but important element of homeostasis. There are numerous reports documenting the composition and role of the gut, skin or vagina microbiome but the role of commensal organisms living in the lungs is relatively unknown. Pulmonary microbiome impact on the immune response of the host organism and may indicate new therapeutic directions. Lung microbiome, by modulating the expression of innate immunity genes, causes an increase in the concentration of IL-5, IL-10, IFNγ and CCL11, affects the TLR4 dependent response of pulmonary macrophages and modulate the production of antibacterial peptides contained in the mucus. It is documented that disorders of the lung microbiome contribute to asthma or chronic obstructive pulmonary disease. However it is known that pulmonary dysbiosis also occurs in critically ill patients. It is possible, therefore, that microbiota-targeted therapy may constitute the future therapeutic direction in ICU.
keywords:

ICU, lung microbiom, lung-gut interaction

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