ISSN: 1734-1922
Archives of Medical Science Special Issues
Current issue Archive Archives of Medical Science
3/2007
 
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abstract:

Invited review
The nephroprotective potential of trimetazidine in chronic inflammation and oxidative stress in renal disease

Jacek Rysz
,
Robert A. Stolarek

Arch Med Sci 2007; 3, 3A: S57-S58
Online publish date: 2008/01/10
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The available studies provide an apparent compilation of diverse and solid research evidence on the possible nephroprotective role of trimetazidine. However, large, randomized, placebo-controlled, preferably multicentre studies are necessary to confirm this hypothesis in non-dialyzed, chronic renal failure and haemodialyzed patients. The extent of the challenge would also be related to specific molecular parameters chosen to demonstrate nephroprotection in the case of trimetazidine.
keywords:

trimetazidine (TMZ), oxidative stress, renal disease, nephroprotection

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