Invited review<BR>Trimetazidine and liver preservation against ischaemia-reperfusion injury

Ismail B. Mosbah; Hassen B. Abdennebi; Mohamed A. Zaouali; Susagna Padrissa-Altes; Carmen Peralta; Joan Roselló-Catafau

ISSN: 1734-1922

Archives of Medical Science Special Issues

Current issue Archive Archives of Medical Science

3/2007

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abstract:

Invited review
Trimetazidine and liver preservation against ischaemia-reperfusion injury

Ismail B. Mosbah

,

Hassen B. Abdennebi

,

Mohamed A. Zaouali

,

Susagna Padrissa-Altes

,

Carmen Peralta

,

Joan Roselló-Catafau

Arch Med Sci 2007; 3, 3A: S59-S61

Online publish date: 2008/01/10

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Trimetazidine is an anti-ischaemic drug used for angina pectoris treatment. Recently, it has been shown that trimetazidine protects against hepatic ischaemia reperfusion injury. Several hypotheses have been proposed to explain the exact hepatoprotective mechanisms but they still remain unclear. This review assesses the possible mechanisms responsible for the increase of the liver’s tolerance against ischaemia-reperfusion injury with special emphasis on: (1) the prevention of oxidative stress and protection of mitochondrial function; (2) the generation of vasoactive mediators such as nitric oxide and endothelins; and finally (3) the preservation of liver energy metabolism.

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Invited reviewTrimetazidine and liver preservation against ischaemia-reperfusion injury

Ismail B. Mosbah , Hassen B. Abdennebi , Mohamed A. Zaouali , Susagna Padrissa-Altes , Carmen Peralta , Joan Roselló-Catafau

ischaemia-reperfusion injury, liver, trimetazidine

Invited review
Trimetazidine and liver preservation against ischaemia-reperfusion injury

Ismail B. Mosbah

,

Hassen B. Abdennebi

,

Mohamed A. Zaouali

,

Susagna Padrissa-Altes

,

Carmen Peralta

,

Joan Roselló-Catafau