Abstract
Irritable bowel syndrome is associated with novel inflammatory markers derived from hemogram parameters
- Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey
- Department of Gastroenterology, Abant Izzet Baysal University Hospital, Bolu, Turkey
Introduction
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is associated with sub-clinical inflammation. Some hemogram parameters are thought to be novel inflammatory markers. We aimed to study novel inflammatory markers derived from hemograms and to compare them to those in healthy subjects.
Material and methods
The platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) of patients with IBS were gathered from a database and compared to those in a healthy population.
Results
The PLR of the IBS group (144 ± 50%) was higher than the PLR of the control group (111 ± 32%; p < 0.001). The PDW of the IBS group (16.3 [1%]) was higher than the PDW of the control group (15.4 [2.4%]; p < 0.001). The NLR of the IBS group (2.2 [1.1%]) was higher than the NLR of the control group (1.8 [0.7%]; p < 0.001). The MLR of the IBS group (0.25 [0.14%]) was higher than the MLR of the control group (0.2 [0.12%]; p < 0.001).
Conclusions
We think that PDW, NLR, PLR, and MLR could all serve as diagnostic tools for IBS. Although the diagnosis of IBS is based on history and clinical findings, the simplicity and low cost of these hemogram tests could provide laboratory support in establishing a diagnosis, especially in suspected cases.
Keywords
irritable bowel syndrome, inflammation, platelet distribution width, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio
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