eISSN: 1896-9151
ISSN: 1734-1922
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abstract:
Clinical research

Is percutaneous computed tomography-guided biopsy sufficient to establish indolent lymphoma transformation?

Petr Dvorak, Petr Hoffmann, Martin Simkovic, Jiri Jandura, Marketa Nova

Online publish date: 2018/12/31
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Introduction
The aim of the study was to retrospectively evaluate the technical features, efficacy, accuracy, and relevant complications of computed tomography-guided biopsies in various anatomical localizations when diagnosing indolent lymphoma transformations, relapses, duplicate malignant diseases or benign processes.

Material and methods
From December 2007 to December 2017, 81 percutaneous biopsy procedures in 72 patients for tumors, sizes 17–232 mm in diameter (median length: 39 mm), were performed in patients with known indolent lymphomas in their clinical history. The patients were men in 41 cases and women in 31 cases, aged 36 to 86 years.

Results
In 79 cases (97.5%; 95% CI: 91.3–99.7) results were true positive or true negative; only 2 interventions (2.5%; 95% CI: 0.3–8.6) were histologically false negative. Transformation was verified in 29 cases (35.8%; 95% CI: 25.4–47.2), relapses in 30 cases (37%; 95% CI: 26.6–48.5), duplicate malignancy in 15 cases (18.5%; 95% CI: 10.8–28.7) and benign processes in 7 cases (8.7%; 95% CI: 3.5–17.0). Eight complications in total were revealed, 7 of which were in consequence of thoracic cavity biopsy. A statistically significant relationship between the complication incidence and anatomical localization in the thoracic cavity was identified (p = 0.0104).

Conclusions
Percutaneous CT guided biopsy performed in patients with a history of indolent lymphoma had high accuracy in establishing the correct diagnosis regarding transformation, relapse, duplicate malignancy or a benign process. Simultaneously, the complication rate was low.

keywords:

lymphoma development, histological types, core needle, Richter’s syndrome, accuracy rate

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