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ISSN: 1642-5758
Anaesthesiology Intensive Therapy
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abstract:
Letter to the Editor

Is the efficacy of remdesivir so different from that of lopinavir-ritonavir in severe COVID-19? The answer by real time-PCR: a narrative review

Tiago Isidoro Duarte
1
,
Cesar Vieira
1
,
Carlos Pimentel
1
,
Mariana Cascão
2
,
Marta Torre
2
,
Joaquim Santos-Lima
2
,
Tânia Sequeira
1
,
Nuno Germano
1
,
Rita Corte-Real
3
,
Luís Bento
2

1.
Polyvalent Intensive Care Unit, Hospital de Curry Cabral, Lisbon, Portugal
2.
Medical Emergency Unit, Hospital de São José, Lisbon, Portugal
3.
Department of Clinical Patology, Hospital de Curry Cabral, Lisbon, Portugal
Anaesthesiol Intensive Ther 2021; 53
Online publish date: 2021/07/23
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This letter discusses the efficacy of current antiviral therapy used in severe COVID-19 infection. Since the first severe cases were documented, several antiviral options have been studied as adjuncts to standard supportive care [1, 2]. Firstly, the combination of lopinavir–ritonavir resurrected from SARS and MERS outbreaks and soon abandoned after the publication of several trials like the randomized controlled trial RECOVERY, which concluded that it was not associated with reductions in 28-day mortality, duration of hospital stay, or risk of progression to invasive mechanical ventilation or death [3]. Remdesivir is currently the only antiviral agent approved for the treatment of COVID-19. It is recommended for use in hospitalized patients who require supplemental oxygen. However, it is not routinely recommended for patients who require mechanical ventilation due to the lack of data showing any benefit at this advanced stage of the disease [4–6].
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