eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
1/2017
vol. 55
 
Share:
Share:
abstract:
Case report

Three cases of ectopic sphenoid sinus pituitary adenoma

Ernest Jan Bobeff
,
Karol Wiśniewski
,
Wielisław Papierz
,
Ludomir Stefańczyk
,
Dariusz Jan Jaskólski

Folia Neuropathol 2017; 55 (1): 60-66
Online publish date: 2017/03/27
View full text Get citation
 
PlumX metrics:
Introduction: Ectopic sphenoid sinus pituitary adenoma is a rare tumour originating from embryologic remnants of Rathke’s pouch. Although it is considered a clinically benign neoplasm, necrosis is encountered in 25% of cases and it can invade adjacent bone structures.

Aims: To establish clinical, radiological and histopathological features of ectopic sphenoid sinus pituitary adenoma.

Material and methods: Analysis of three cases: two females and one man, aged 61-70.

Results: One patient presented with a unilateral hearing loss, the other two with headache and vertigo. They all suffered from type 2 diabetes mellitus. Neurological examination revealed no abnormality. Radiological imaging showed a sphenoid sinus space-occupying soft-tissue lesion with bone erosion in 2 cases and empty sella in 2 patients whereas one had a normal pituitary gland. All were operated on via the transnasal approach. Total resection was achieved in one patient and subtotal in two; in two cases we observed intact sellar dura and in one intact sellar floor. Histopathology showed immunoreactivity for synaptophysin in all cases and cytokeratin in two. The Ki-67 index was less than 2%. Immunohistochemical staining demonstrated growth hormone cells in all cases whereas prolactin and adrenocorticotropin in two. The patients were discharged home in good condition with no neurological deficits.

Conclusions: Ectopic sphenoid sinus pituitary adenoma should always be considered in differential diagnosis of sphenoid sinus lesion in the elderly, especially in coexistence with empty sella or type 2 diabetes mellitus. Since ectopic sphenoid sinus pituitary adenoma is a benign lesion, surgical removal is an effective treatment.



keywords:

sphenoid sinus, empty sella, neuroendocrine markers, plurihormonal, ectopic pituitary adenoma

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.