eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
6/2012
vol. 16
 
Share:
Share:
abstract:
Review paper

Crizotinib in the treatment of non-small-cell lung cancer
[Polish version: Kryzotynib w leczeniu chorych na niedrobno komórkowego raka płuca p. 485]

Adam Płużański
,
Aleksandra Piórek
,
Maciej Krzakowski

Wspolczesna Onkol 2012; 16 (6): 480–484
[Polish version: Wspolczesna Onkol 2012; 16 (6): 485-490]
Online publish date: 2013/01/04
View full text Get citation
 
PlumX metrics:
Recent studies have demonstrated the benefit of EGFR tyrosine kinase inhibitors in the treatment of advanced non-small-cell lung cancer (NSCLC). The role of activation of the anaplastic lymphoma kinase (ALK) pathway and the presence of the fusion gene EML4-ALK are new molecular targets in studies into the pathogenesis and treatment of NSCLC. ALK gene rearrangement is observed in 3–5% of NSCLC patients. Crizotinib is an oral inhibitor of ALK kinase activity, approved for the treatment of NSCLC patients with ALK gene rearrangement. Crizotinib treatment has resulted in a progression-free survival of 7–10 months with 50–60% objective response rate. The present paper gives an overview of literature reports on the role of crizotinib in the treatment of NSCLC patients harbouring a molecular defect in the ALK gene. Molecular diagnosis of ALK-associated aberrations, results of clinical trials of different phases assessing the efficacy and safety profile of crizotinib are also discussed. Attention is given to the likely causes of drug resistance and management strategies in patients with treatment failure.
keywords:

crizotinib, ALK, fusion gene, non-small-cell lung cancer, tyrosine kinase inhibitor

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.