eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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SCImago Journal & Country Rank
2/2016
vol. 67
 
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abstract:
Case report

Langerhans cell sarcoma: a case report and review of the literature

David T. Liu
,
Joerg Friesenbichler
,
Lukas A. Holzer
,
Bernadette Liegl-Atzwanger
,
Christine Beham-Schmid
,
Andreas Leithner

Pol J Pathol 2016; 67 (2): 172-178
Online publish date: 2016/08/02
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We present the case of a 62-year-old male patient with a three-month history of pain in the left shoulder. Magnetic resonance imaging of the left scapula showed an osteo-destructive lesion. H&E stained sections revealed a Langerhans cell sarcoma, and immunohistochemistry was performed additionally; CD68, CD163, CD14, fascin, HLA-DR, lysozyme, S100 CD1a and langerin showed a positive reaction, while CD20, CD30, CD34, CD31, pan-cytokeratin, AE/1AE3, SMA, desmin, EMA, ERG, INI-1, CD21, CD4, PLAP, MPO and CD117c were negative. We suggested palliative treatment with chemotherapy and radiation. The patient refused any treatment and died 2 weeks later.
keywords:

Langerhans cell sarcoma, histiocytic cell tumour,diagnosis, treatment, histology

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