eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
1/2019
vol. 15
 
Share:
Share:
more
 
 
abstract:
Clinical research

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches – a preliminary report

Joanna Sordyl, Ilona Kopyta, Beata Sarecka-Hujar, Tomasz Francuz, Paweł Matusik, Ewa Małecka-Tendera

Arch Med Sci 2019; 15, 1: 120–125
Online publish date: 2018/03/02
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idiopathic headaches.

Material and methods
The study population comprised 65 children (39 with idiopathic headaches and 26 healthy children). Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) cholesterol and triacylglycerol (TG) levels were measured in every patient. Brain-derived neurotrophic factor (BDNF), soluble CD40 ligand (sCD40L), endothelial plasminogen activator inhibitor (serpin E1/PAI I) and vascular endothelial growth factor (VEGF) blood level measurements were performed in 34 children.

Results
Children with headaches had higher BMI z-scores (0.2 vs. –1.14; p = 0.006). TC level was lower in patients with headaches (121.04 mg/dl vs. 146.87 mg/dl, p = 0.019). No differences in concentrations of TG, HDL or LDL were found. BDNF was significantly higher in the studied group (171.57 pg/ml vs. 64.04 pg/ml, p = 0.012). The VEGF was higher in boys with headaches than in girls (368.27 pg/ml vs. 142.86 pg/ml, p = 0.011). There were no differences in levels of VEGF, sCD40L or PAI-1 between groups.

Conclusions
Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls.

keywords:

children, atherosclerosis, dyslipidemia, headache

references:
Brna PM, Dooley JM. Headaches in the pediatric population. Semin Pediatr Neurol 2006; 13: 222-30.
Villalon CM, Centurion D, Valdivia LF, de Vries P, Saxena PR. Migraine: pathophysiology, pharmacology, treatment and future trends. Curr Vasc Pharmacol 2003; 1: 71-84.
Scher AI, Gudmundsson LS, Sigurdsson S, et al. Migraine headache in middle age and late life brain infarcts. JAMA 2009; 24: 2563-70.
Glueck MD, Bates SR. Migraine in children: association with primary and familial dyslipoproteinemias. Pediatrics 1986; 77: 316-21.
Nelson KB, Richardson AK, He J, Lateef TM, Khoromi S, Merikangas KR. Headache and biomarkers predictive of vascular disease in a representative sample of US children. Arch Pediatr Adolesc Med 2010; 164: 358-62.
Chaldakov GN, Fiore M, Hristova MG, Aloe L. Metabotrophic potential of neurotrophins: implication in obesity and related diseases? Med Sci Monit 2003; 9: 19-21.
Mannia L, Nikolova V, Vyagova D, Chaldakov GN, Aloe L. Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes. Int J Cardiol 2005; 102: 169-71.
Li ST, Pan J, Hua XM, et al. Endothelial nitric oxide synthase protects neurons against ischemic injury through regulation of brain-derived neurotrophic factor expression. CNS Neurosci Therap 2014; 20: 154-64.
Fu CP, Sheu WH, Lee IT, et al. Effects of weight loss on epicardial adipose tissue thickness and its relationship between serum soluble CD40 ligand levels in obese men. Clin Chim Acta 2013; 421: 98-103.
Baena-Fustegueras JA, Pardina E, Balada E, et al. Soluble CD40 ligand in morbidly obese patients effect of body mass index on recovery to normal levels after gastric bypass surgery. JAMA Surg 2013; 148: 151-6.
Unek IT, Bayraktar F, Solmaz D, et al. The levels of soluble CD40 ligand and C-reactive protein in normal weight, overweight and obese people. Clin Med Res 2010; 8: 89-95.
Wang JH, Zhang YW, Zhang P, et al. CD40 ligand as a potential biomarker for atherosclerotic instability. Neurol Res 2013; 35: 693-700.
Reuter B, Rodemer C, Grudzenski S, et al. Temporal profile of matrix metalloproteinases and their inhibitors in a human endothelial cell culture model of cerebral ischemia. Cerebrovasc Dis 2013; 35: 514-20.
Karasek D, Vaverkova H, Halenka M, et al. Prothrombotic markers in asymptomatic dyslipidemic subjects. J Thromb Thrombolysis 2011; 31: 27-36.
Soinne L, Saimanen E, Malmberg-Ceder K, et al. Association of the fibrinolytic system and hemorheology with symptoms in patients with carotid occlusive disease. Cerebrovasc Dis 2005; 20: 172-9.
Gürger M, Atescelik M, Yılmaz M, et al. Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department? Arch Med Sci 2018; 14: 307-12.
Hogas S, Bilha S, Branisteanu D, et al. Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3. Arch Med Sci 2016; 13: 897-913.
Tsai CL, Chou CH, Lee PJ, et al. The potential impact of primary headache disorders on stroke risk. J Headache Pain 2016; 17: 108.
Larrosa-Campo D, Ramon-Carbajo C, Para-Prieto M, Calleja-Puerta S, Cernuda-Morollon E, Pascual J. Migraine as a vascular risk factor. Rev Neurol 2012; 55: 349-58.
Guillan M, Alonso-Canovas A, Gonzalez-Valcarcel J, et al. Stroke mimics treated with thrombolysis: further evidence on safety and distinctive clinical features. Cerebrovasc Dis 2012; 34: 115-20.
Partap S. Stroke and cerebrovascular complications in childhood cancer survivors. Semin Pediatr Neurol 2012; 19: 18-24.
Kopyta I, Sarecka-Hujar B, Emich-Widera E, Marszał E, Zak I. Association between lipids and fibrinogen levels and ischemic stroke in the population of the Polish children with arteriopathy and cardiac disorders. Wiad Lek 2010; 63: 17-23.
Nelson KB, Richardson AK, He J, et al. Headache and biomarkers predictive of vascular disease in a representative sample of US children. Arch Pediatr Adolesc Med 2010; 164: 358-62.
Ozdemir O, Yakut A, Dinleyici EC, Aydogdu SD, Yarar C, Colak O. Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid. Eur J Pediatr 2011; 170: 873-7.
Winsvold BS, Hagen K, Aamodt AH, Stovner LJ, Holmen J, Zwart JA. Headache, migraine and cardiovascular risk factors: the HUNT study. Eur J Neurol 2011; 18: 504-11.
Nago N, Ishikawa S, Goto T, et al. Cholesterol is associated with mortality from stroke, heart disease, and cancer: the Jichi Medical School Cohort Study. J Epidemiol 2011; 21: 67-74.
Pikula A, Beiser AS, Chen TC, et al. Serum BDNF and VEGF levels are associated with Risk of Stroke and Vascular Brain Injury: Framingham Study. Stroke 2013; 44: 2768-75.
Bonora E, Kiechl S, Willeit J, et al. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes 1998; 47: 1643-9.
Sun GZ, Li Z, Guo L, Sun YX. High prevalence of dyslipidemia and associated risk factors among rural Chinese adults. Lipids Health Dis 2014; 13: 189.
Pacifico L, Bonci E, Andreoli G, et al. Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents. Nutr Metab Cardiovasc Dis 2014; 24: 737-43.
Ogden CL, Carroll MD, Flegal KM. High body mass index for age among US children and adolescents, 2003–2006. JAMA 2008; 299: 2442-3.
Li C, Ford ES, Zhao G, Croft JB, Balluz LS, Mokdad AH. Prevalence of self-reported clinically diagnosed sleep apnea according to obesity status in men and women: National Health and Nutrition Examination Survey, 2005–2006. Prev Med 2010; 51: 18-23.
Jiraskova N, Rozsival P. Idiopathic intracranial hypertension in pediatric patients. Clin Ophthalmol 2008; 2: 723-6.
Spear BA, Barlow SE, Ervin C, et al. Recommendations for treatment of child and adolescent overweight and obesity. Pediatrics 2007; 120: 254-88.
Bigal ME, Lipton RB. Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology 2006; 67: 252-7.
Bigal ME, Lipton RB, Holland PR, Goadsby PJ. Obesity, migraine, and chronic migraine: possible mechanisms of interaction. Neurology 2007; 68: 1851-61.
Peres MF, Lerario DD, Garrido AB, Zukerman E. Primary headaches in obese patients. Arq Neuropsiquiatr 2005; 63: 931-3.
Hershey AD, Powers SW, Nelson TD, et al. Obesity in the pediatric headache population: a multicenter study. Headache 2009; 49: 170-7.
Kinik ST, Alehan F, Erol I, Kanra AR. Obesity and paediatric migraine. Cephalalgia 2010; 30: 105-9.
Pinhas-Hamiel O, Frumin K, Gabis L, et al. Headaches in overweight children and adolescents referred to a tertiary-care center in Israel. Obesity 2008; 16: 659-63.
Lasek-Bal A, Jedrzejowska-Szypulka H, Rozycka J, et al. Low concentration of BDNF in the acute phase of ischemic stroke as a factor in poor prognosisin terms of functional status of patients. Med Sci Monit 2015; 21: 3900-5.
Chaldakov GN, Fiore M, Stankulov IS, et al. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Arch Physiol Biochem 2001; 109: 357-60.
Roy H, Bhardwaj S, Yla-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett 2006; 580:
2879-87.
Elias I, Franckhauser S, Bosch F. New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance. Adipocyte 2013; 2: 109-12.
FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe