Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat

Jodok Matthias Grueneberger; Tobias Fritz; Cheng Zhou; Sebastian Meyer; Iwona Karcz-Socha; Tomasz Sawczyn; Dominica Stygar; Matthias Goos; Ulrich Theodor Hopt; Simon Küsters

doi:10.5114/wiitm.2011.32925

eISSN: 2299-0054
ISSN: 1895-4588

Videosurgery and Other Miniinvasive Techniques

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abstract:

Original paper

Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat

Jodok Matthias Grueneberger

,

Tobias Fritz

,

Cheng Zhou

,

Sebastian Meyer

,

Iwona Karcz-Socha

,

Tomasz Sawczyn

,

Dominica Stygar

,

Matthias Goos

,

Ulrich Theodor Hopt

,

Simon Küsters

Videosurgery Miniinv 2013; 8 (2): 130-138

DOI: https://doi.org/10.5114/wiitm.2011.32925

Online publish date: 2013/01/21

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AMA

Grueneberger J, Fritz T, Zhou C, et al. Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat. Videosurgery and Other Miniinvasive Techniques. 2013;8(2):130-138. doi:10.5114/wiitm.2011.32925.

APA

Grueneberger, J., Fritz, T., Zhou, C., Meyer, S., Karcz-Socha, I.,  & Sawczyn, T. et al. (2013). Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat. Videosurgery and Other Miniinvasive Techniques, 8(2), 130-138. https://doi.org/10.5114/wiitm.2011.32925

Chicago

Grueneberger, Jodok Matthias, Tobias Fritz, Cheng Zhou, Sebastian Meyer, Iwona Karcz-Socha, Tomasz Sawczyn,  and Dominica Stygar et al. 2013. "Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat". Videosurgery and Other Miniinvasive Techniques 8 (2): 130-138. doi:10.5114/wiitm.2011.32925.

Harvard

Grueneberger, J., Fritz, T., Zhou, C., Meyer, S., Karcz-Socha, I., Sawczyn, T., Stygar, D., Goos, M., Hopt, U.,  and Küsters, S. (2013). Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat. Videosurgery and Other Miniinvasive Techniques, 8(2), pp.130-138. https://doi.org/10.5114/wiitm.2011.32925

MLA

Grueneberger, Jodok Matthias et al. "Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat." Videosurgery and Other Miniinvasive Techniques, vol. 8, no. 2, 2013, pp. 130-138. doi:10.5114/wiitm.2011.32925.

Vancouver

Grueneberger J, Fritz T, Zhou C, Meyer S, Karcz-Socha I, Sawczyn T et al. Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat. Videosurgery and Other Miniinvasive Techniques. 2013;8(2):130-138. doi:10.5114/wiitm.2011.32925.

PlumX metrics:

Introduction: Fast delivery of food to the terminal ileum is thought to be pathophysiologically responsible for type 2 diabetes remission after obesity surgery. Imitating this effect, ileal transposition (IT) is designed as initiating diabetes remission for non-obese patients.

Aim: To date, it is not clear which length of the transposed segment achieves the best glucose lowering results. As previous rodent data mostly rely on a 10 cm IT, the current study evaluated a long segment IT (20 cm) in the diabetic obese Zucker rat.

Material and methods: Twenty male diabetic obese Zucker rats (Crl:ZUC-Leprfa) were randomly assigned to undergo either a long segment (20 cm; ~ 50% of ileum) IT or sham surgery. Glucose control was determined by an oral glucose tolerance test (OGTT) on day –7, 0, 14 and 20. Analysis of the incretin hormones glucagon-like peptide 1 (GLP-1), peptide YY (PYY) and insulin was included in the first and third OGTT.

Results: Ileal transposition animals showed an early improvement of glucose control after 14 days (area under the curve: IT vs. baseline 314.7 ±229.0 mmol/l × min vs. 564.6 ±268.5 mmol/l × min; p < 0.05). Compared to sham animals, glucose-stimulated GLP-1 and PYY levels were raised (5.75 ±3.73 pmol/l vs. 18.52 ±14.22 pmol/l, p < 0.05; 129.7 ±64.62 pmol/l vs. 164.0 ±62.26 pmol/l, p < 0.05). Body weight gain from postoperative day 5 was greater for sham animals (50.22 ±20.93 γ vs. 16.4 ±25.93 g; p < 0.01).

Conclusions: Long segment IT shows a rapid rise in GLP-1 and PYY levels, thus leading to early amelioration of glucose control.

keywords:

Long segment ileal transposition leads to early amelioration of glucose control in the diabetic obese Zucker rat

Jodok Matthias Grueneberger , Tobias Fritz , Cheng Zhou , Sebastian Meyer , Iwona Karcz-Socha , Tomasz Sawczyn , Dominica Stygar , Matthias Goos , Ulrich Theodor Hopt , Simon Küsters

ileal transposition, ileal transposition, type 2 diabetes mellitus, obesity surgery, metabolic surgery

Jodok Matthias Grueneberger

,

Tobias Fritz

,

Cheng Zhou

,

Sebastian Meyer

,

Iwona Karcz-Socha

,

Tomasz Sawczyn

,

Dominica Stygar

,

Matthias Goos

,

Ulrich Theodor Hopt

,

Simon Küsters