eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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5/2020
vol. 16
 
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Cardiology
abstract:
Letter to the Editor

Long-term outcome of repeated septal reduction therapy after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: insight from the Euro-ASA registry

Josef Veselka
1
,
Lothar Faber
2
,
Max Liebregts
3
,
Robert Cooper
4
,
Jaroslav Januska
5
,
Jan Krejci
6
,
Maciej Dabrowski
7
,
Peter Riis Hansen
8
,
Hubert Seggewiss
2, 9
,
Dieter Horstkotte
2
,
Eva Hansvenclova
1
,
Henning Bundgaard
10
,
Jurriën ten Berg
3
,
Morten Kvistholm Jensen
10

1.
Department of Cardiology, Second Medical School, Charles University, University Hospital Motol, Prague, Czech Republic
2.
Department of Cardiology, Heart and Diabetes Centre NRW, Ruhr-University Bochum, Bad Oyenhausen, Germany
3.
Department of Cardiology, St. Antonius Hospital Nieuwegein, Nieuwegein, the Netherlands
4.
Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, England
5.
Cardiocentre Podlesí, Třinec, Czech Republic
6.
First Department of Internal Medicine/Cardioangiology, International Clinical Research Centre, St. Anne’s University Hospital and Masaryk University, Brno, Czech Republic
7.
Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland
8.
Department of Cardiology, Gentofte Hospital, Copenhagen University Hospital, Hellerup, Denmark
9.
Department of Internal Medicine, Juliusspital Wuerzburg, Germany
10.
Unit for Inherited Cardiac Diseases, Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Arch Med Sci 2020; 16 (5): 1239–1242
Online publish date: 2020/08/10
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Two-thirds of patients with hypertrophic cardiomyopathy (HCM) have a significant left ventricular outflow tract (LVOT) obstruction that may be treated with alcohol septal ablation (ASA) dependent on symptoms [1]. However, some degree of obstruction may remain after ASA and if the patient remains symptomatic repeated septal reduction therapy (RSRT) may be indicated [1–5]. The outcome of RSRT remains unknown. In this study, we sought to determine the long-term outcomes of patients treated with ASA or myectomy after previous ASA.
A total of 1385 consecutive patients (48% women, mean age: 58 ±14 years) from nine European centres (Euro-ASA registry) who had been treated once with ASA as first time septal reduction therapy were enrolled in the study. We identified 145 (10%) patients who subsequently underwent RSRT, including 99 (68%) who underwent re-ASA, 31 (21%) who underwent myectomy, 12 (8%) who underwent re-ASA and myectomy, and 3 (2%) who underwent two further ASA procedures.
Patients were divided into those who had undergone only the initial ASA (group A, 1240 patients) and those who had undergone RSRT (group B, 145 patients). The primary end-point was major adverse cardiovascular events (MACE), defined as death related to any cardiovascular disease, sudden death, an appropriate implantable cardioverter-defibrillator discharge, resuscitation for ventricular fibrillation or death due to an unknown cause. Secondary endpoints were clinical symptoms and echocardiographic variables and number of implanted pacemakers at the last clinical check-up.
The septal reduction procedure was performed as described previously [1–6]. The indication for RSRT was at the discretion of each participating centre. Most patients underwent a routine clinical examination 3–6 months after ASA and then once per year including echocardiography [7–9]. All adverse events were confirmed by reviewing the medical records and/or national death registries.
Student’s t-test, 2 test and Kaplan-Meier analysis were used as appropriate. The long-term occurrence of MACE was estimated using the Kaplan-Meier method, with the curves of groups A and B adjusted for age at ASA (60 years), baseline LVOT gradient (70 mm Hg), baseline septum thickness (20 mm) and baseline NYHA class (2.5). A p-value of < 0.05 was considered statistically significant.
A total of 1385 consecutive patients underwent ASA. A total of 12 (0.9%) patients died within 30 days after the...


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