eISSN: 2299-0054
ISSN: 1895-4588
Videosurgery and Other Miniinvasive Techniques
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2/2022
vol. 17
 
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abstract:
Original paper

Lymphovascular invasion predicts disease-specific survival in node-negative esophageal squamous cell carcinoma patients after minimally invasive esophagectomy

Ying-Jian Wang
1
,
Xiao-Long Zhao
1
,
Kun-Kun Li
1
,
Xue-Hai Liu
1
,
Tao Bao
1
,
Wei Guo
1

1.
Department of Thoracic Surgery, Daping Hospital, Army Medical University, Chongqing, China
Videosurgery Miniinv 2022; 17 (2): 309–316
Online publish date: 2022/01/19
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Introduction
Lymphovascular invasion (LVI) is reported to be a potential prognostic predictor in esophageal squamous cell carcinoma (ESCC) patients. Aim: To investigate the prognostic value of LVI in ESCC node-negative patients after minimally invasive esophagectomy (MIE).

Material and methods
1406 consecutive ESCC patients who underwent MIE were reviewed retrospectively. After exclusion, 880 patients were enrolled, and 298 node-negative patients were used for the further analysis. The Kaplan-Meier method was used to examine the survival difference. Univariate and multivariate analyses were performed to identify prognostic predictors.

Results
LVI was observed in 29.4% of all patients. Totally, the proportion of LVI was increased with advanced T (p < 0.01) and N (p < 0.01) stage and poor tumor differentiation (p < 0.01). In the node-negative patients, a similar result was obtained in T stage (p = 0.0252) and tumor differentiation (p = 0.0080). In survival analysis, the disease-specific survival (DSS) (p = 0.0146) rate was significantly lower in node-negative patients with LVI than in those without. The difference was absent when calculating disease-free survival (DFS) (p = 0.0796). Additionally, the presence of LVI was associated with lower DSS (p = 0.0187) but not DFS (p = 0.0785) in univariate analysis in node-negative patients. Moreover, in multivariate Cox regression analysis, the presence of LVI was identified as an independent prognostic factor only in DSS (p = 0.0496) but not in DFS (p = 0.5670) in node-negative patients.

Conclusions
LVI is associated with shorter DSS and an independent prognostic factor in ESCC node-negative patients after MIE.

keywords:

lymphovascular invasion, esophageal squamous cell carcinoma, minimally invasion esophagectomy, survival, prognostic value

  
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