The natural history of Marjolin’s ulcer involves an initial skin injury leading to a non-healing or recurrent ulcer. It is a disease that develops from chronic wounds and cutaneous scars, and it is not exclusively linked to burn injuries. Marjolin’s ulcer is classified as acute if it appears within the first 12 months after the initial injury, or chronic if it develops thereafter, with the chronic form being more common. The classic clinical triad consists of nodularity, induration, and ulceration persisting for more than 3 months.

The lower limb is the most commonly affected site. Mohs surgery is considered the standard treatment, although further management strategies depend on lymph node involvement and the presence of metastases. No established consensus exists regarding adjuvant or neoadjuvant therapy.

Prevention of ulceration remains the most effective treatment approach. Prognosis is influenced by coexisting factors such as metastasis, lymph node involvement, and histologic grading. Based on this background, we present a case of 74-year-old woman with a Marjolin’s ulcer arising from an old burn scar.