eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
3/2016
vol. 67
 
Share:
Share:
more
 
 
abstract:
Original paper

Mast cells influence neoangiogenesis in prostatic cancer independently of ERG status

Katarzyna Miłek
,
Karolina Kaczmarczyk-Sekuła
,
Aleksandra Strzępek
,
Grzegorz Dyduch
,
Magdalena Białas
,
Joanna Szpor
,
Tomasz Gołąbek
,
Tomasz Szopiński
,
Piotr Chłosta
,
Krzysztof Okoń

Pol J Pathol 2016; 67 (3): 244-249
Online publish date: 2016/11/25
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
A significant proportion of prostatic adenocarcinomas show recurrent translocation leading to ERG expression. Previously we found that ERG+ cases have higher microvessel density than negative ones. One factor influencing angiogenesis in cancer is mast cells. The aim of the present study was to evaluate the relationship between microvessels, mast cells and ERG status.

Tissue microarrays prepared from 113 radical prostatectomy specimens were analyzed with immunohistochemistry for CD31, tryptase and chymase. Vascular profiles and tryptase-positive and chymase-positive cells were counted.

The average number of tryptase-positive cells was 28.93/mm2 and chymase-positive cells 9.91/mm2. The average number of CD31+ vascular profiles was 352.66/mm2. The average number of tryptase-positive cells was 26.35/mm2 for ERG– cases and 32.12/mm2 for ERG+ cases. The average number of chymase-positive cells was 8.14/mm2 for ERG– cases and 12.06/mm2 for ERG+ cases. The average number of CD31+ vascular profiles was 321.34/mm2 for ERG– cases and 390.74/mm2 for ERG+ cases. The number of CD31+ vascular profiles was positively correlated with the number of tryptase-positive and chymase-positive cells (R = 0.26 and R = 0.20).

In summary, we demonstrated an interrelationship between mast cells, microvascular density and ERG status in prostatic carcinoma.
keywords:

mast cell, chymase, tryptase, ERG, prostate cancer, microvessel density, CD31

FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe