Mechanism of Gut-Skin Axis in Atopic Dermatitis: a Narrative
Review

Prayogi Susanto; Andi Hardianty; Nurelly Waspodo; Widya Widita; Muhlis Muhlis; Khairuddin Djawad; Anis Anwar

doi:10.5114/dr.2025.160181

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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6/2025
vol. 112

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abstract:

Review article

Mechanism of Gut-Skin Axis in Atopic Dermatitis: a Narrative Review

Prayogi M. Susanto

¹

,

Andi Hardianty

^{1, 2}

,

Nurelly N. Waspodo

¹

,

Widya Widita

^{1, 2}

,

Muhlis Muhlis

¹

,

Khairuddin Djawad

¹

,

Anis I. Anwar

^{1, 2}

Department of Dermatology, Venereology and Aesthetic, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Department of Dermatology, Venereology and Aesthetic, Hasanuddin University Hospital, Makassar, Indonesia

Dermatol Rev/Przegl Dermatol 2025, 112, 361-367

DOI: https://doi.org/10.5114/dr.2025.160181

Online publish date: 2026/02/28

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Atopic dermatitis is a chronic, relapsing inflammatory dermatosis with a multifactorial etiology involving environmental, genetic, and immunological factors. Growing evidence suggests that immune dysregulation in atopic dermatitis is closely associated with alterations in the gut microbiome. Early gut microbial colonization plays a critical role in immune system development and may influence skin inflammation through bidirectional communication along the gut-skin axis. This review summarizes current evidence on the role of the gut microbiome in the pathogenesis of atopic dermatitis.

keywords:

atopic dermatitis, gut-skin axis, gut microbiome, skin microbiome

Indeks osobowy

Mechanism of Gut-Skin Axis in Atopic Dermatitis: a Narrative Review

Prayogi M. Susanto 1 , Andi Hardianty 1, 2 , Nurelly N. Waspodo 1 , Widya Widita 1, 2 , Muhlis Muhlis 1 , Khairuddin Djawad 1 , Anis I. Anwar 1, 2

atopic dermatitis, gut-skin axis, gut microbiome, skin microbiome

Prayogi M. Susanto

¹

,

Andi Hardianty

^{1, 2}

,

Nurelly N. Waspodo

¹

,

Widya Widita

^{1, 2}

,

Muhlis Muhlis

¹

,

Khairuddin Djawad

¹

,

Anis I. Anwar

^{1, 2}