Melanin and lipofuscin as hallmarks of skin aging

Anna Skoczyńska; Elżbieta Budzisz; Ewa Trznadel-Grodzka; Helena Rotsztejn

doi:10.5114/ada.2017.67070

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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2/2017
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abstract:

Review paper

Melanin and lipofuscin as hallmarks of skin aging

Anna Skoczyńska

,

Elżbieta Budzisz

,

Ewa Trznadel-Grodzka

,

Helena Rotsztejn

Adv Dermatol Allergol 2017; XXXIV (2): 97-103

DOI: https://doi.org/10.5114/ada.2017.67070

Online publish date: 2017/04/13

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Discoloration are symptoms of skin aging. They are connected with presence of melanin and lipofuscin, whose excess and abnormal distribution in the skin cause dark spots to appear. Melanin is formed under the influence of tyrosinase during melanogenesis. Its content changes with age, which may be a result of menopause. Lipofuscin is another example of the age pigment. It is composed of proteins, lipids and carbohydrates. It is described as an age pigment because its content increases with age. The formation and accumulation of lipofuscin is inevitable and leads to cell and homeostasis dysfunction because it reduces the proteasome activity.

keywords:

Melanin and lipofuscin as hallmarks of skin aging

Anna Skoczyńska , Elżbieta Budzisz , Ewa Trznadel-Grodzka , Helena Rotsztejn

melanin, lipofuscin, melanogenesis, lipofuscinogenesis, pigments, skin aging

Anna Skoczyńska

,

Elżbieta Budzisz

,

Ewa Trznadel-Grodzka

,

Helena Rotsztejn