eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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abstract:
State of the art paper

Mesothelin-targeted CAR-T cells for adoptive cell therapy of solid tumors

Gui-Zhen Zhang, Tian-Fang Li, Shuang-Yin Han

Arch Med Sci
Online publish date: 2019/05/08
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Significant progresses have been made in adoptive cell therapy with CAR-T cells for cancers, especially for hematological malignancies. However, the treatment of solid tumors still poses a tremendous challenge and remains an unmet medical need. Several factors are held responsible for the inadequate responses: tumor heterogeneity, inefficient homing of T cells to tumor tissues, immunosuppressive microenvironment and the shortage of specific antigens shortage. Mesothelin is a cell-surface glycoprotein highly expressed in many types of solid tumors. As such, it has attracted much attention as a molecular target in cancer immunotherapy. Here, we delineate the barriers imposed by solid tumors on CARs, outline the rationale of mesothelin as a target for immunotherapy, summarize the preclinical and clinical results of mesothelin-targeted therapies, and extrapolate the expected results of CAR-T cells directed against mesothelin for solid tumors.
keywords:

mesothelin, adoptive cell therapy, chimeric antigen receptor, solid tumors

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