Methotrexate in the treatment of atopic dermatitis

Roman Nowicki; Elżbieta Grubska-Suchanek; Aleksandra Wilkowska; Dmitrij F. Khvorik; Magdalena Trzeciak

doi:10.5114/ada.2025.149551

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Methotrexate in the treatment of atopic dermatitis

Roman J. Nowicki

^{1, 2}

,

Elżbieta Grubska-Suchanek

²

,

Aleksandra Wilkowska

²

,

Dmitrij F. Khvorik

³

,

Magdalena Trzeciak

^{1, 2}

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Poland
Department of Dermatology, Venereology and Allergology, University Clinical Centre, Gdansk, Poland
Department of Dermatovenereology, The Grodno State Medical University, Grodno, Belarus

Adv Dermatol Allergol 2025; XLII (3): 243-247

DOI: https://doi.org/10.5114/ada.2025.149551

Online publish date: 2025/04/15

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Atopic dermatitis (AD) is a common inflammatory skin disease. Most cases start in children although some have been reported in adults. Moderate to severe cases of AD not responding to topical treatments may need systemic therapy. Methotrexate may be considered in patients with severe AD who did not achieve the expected improvement after cyclosporine, or who had adverse effects and no possibility of biological treatment with monoclonal antibodies or Janus kinase inhibitors.

keywords:

Methotrexate in the treatment of atopic dermatitis

Roman J. Nowicki 1, 2 , Elżbieta Grubska-Suchanek 2 , Aleksandra Wilkowska 2 , Dmitrij F. Khvorik 3 , Magdalena Trzeciak 1, 2

atopic dermatitis, systemic therapy, methotrexate

Roman J. Nowicki

^{1, 2}

,

Elżbieta Grubska-Suchanek

²

,

Aleksandra Wilkowska

²

,

Dmitrij F. Khvorik

³

,

Magdalena Trzeciak

^{1, 2}