MicroRNA-20b promotes the accumulation of CD11b+Ly6G+Ly6C<sup>low</sup> myeloid-derived suppressor cells in asthmatic mice

Hua Ma; Shujun Guo; Yulan Luo; Yimeng Wang; Helong Wang; Jing He; Jie Tang; Lin Shen; Chuanwang Song

doi:10.5114/ceji.2017.67316

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

Editorial System

Submit your Manuscript

1/2017
vol. 42

Send email

Copy url:

abstract:

Experimental immunology

MicroRNA-20b promotes the accumulation of CD11b+Ly6G+Ly6C^low myeloid-derived suppressor cells in asthmatic mice

Hua Ma

,

Shujun Guo

,

Yulan Luo

,

Yimeng Wang

,

Helong Wang

,

Jing He

,

Jie Tang

,

Lin Shen

,

Chuanwang Song

(Cent Eur J Immunol 2017; 42 (1): 30-38)

DOI: https://doi.org/10.5114/ceji.2017.67316

Online publish date: 2017/05/08

View full text Get citation

PlumX metrics:

miR-20b is a member of the miR-106a-363 gene cluster, which has been shown to play an important role in a variety of diseases, including cancer, inflammation, and autoimmune diseases. Our previous study indicated that miR-20b has an inhibitory effect on airway inflammation in asthmatic mice, but the exact mechanism is unclear. In this study, we report that the ratio of CD11b+Ly6G+Ly6C^low cells, but not the amount of CD11b+Ly6C+Ly6G– cells, was increased in the lung tissue of asthmatic mice after intranasal instillation with miR-20b mimics, while Th2-type cytokines (interleukin (IL)-4 and IL-13) were significantly decreased in the bronchoalveolar lavage fluid. In addition, the transcription factor CREB regulated the expression of miR-20b. Our findings suggest that miR-20b can induce the accumulation of myeloid-derived suppressor cells in the lungs of asthmatic mice, which may be a mechanism by which miR-20b inhibits airway inflammation in asthmatic mice. Thus, miR-20b may be used as a target for the effective treatment of asthma in the future.

keywords:

MicroRNA-20b promotes the accumulation of CD11b+Ly6G+Ly6Clow myeloid-derived suppressor cells in asthmatic mice

Hua Ma , Shujun Guo , Yulan Luo , Yimeng Wang , Helong Wang , Jing He , Jie Tang , Lin Shen , Chuanwang Song

asthma, MiR-20b, myeloid-derived suppressor cells (MDSCs), allergic airway inflammation

MicroRNA-20b promotes the accumulation of CD11b+Ly6G+Ly6C^low myeloid-derived suppressor cells in asthmatic mice

Hua Ma

,

Shujun Guo

,

Yulan Luo

,

Yimeng Wang

,

Helong Wang

,

Jing He

,

Jie Tang

,

Lin Shen

,

Chuanwang Song