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eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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2/2021
vol. 59
 
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abstract:
Case-based review

Microvascular damage – a marker of specific organ involvement in mixed connective tissue disease?

Sylwia Ornowska
1
,
Marek Chojnowski
1
,
Anna Felis-Giemza
1
,
Łukasz Dudek
2
,
Marzena Olesińska
1

1.
Department of Systemic Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
2.
Medical University of Warsaw, Poland
Reumatologia 2021; 59, 2: 115–120
Online publish date: 2021/04/27
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Mixed connective tissue disease (MCTD) is a complex entity, which incorporates features of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc) and polymyositis/dermatomyositis (PM/DM). Nailfold videocapillaroscopy (NVC) is a simple, safe and non-invasive technique of capillary vessel assessment, allowing for qualitative and quantitative assessment of microcirculation. NVC plays a pivotal role in the diagnostic algorithm of connective tissue diseases, especially in systemic sclerosis (SSc). Numerous studies have shown a correlation between organ involvement and disease progression in SSc.

In the current literature, there are limited data on relationship between NVC and organ involvement in MCTD patients. In the present article the relevant literature describing NVC examination in patients with MCTD and comparisons with some clinical situations are discussed.
keywords:

systemic sclerosis, connective tissue disease, microscopy, microvascular damage







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