eISSN: 1731-2531
ISSN: 1642-5758
Anaesthesiology Intensive Therapy
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
3/2022
vol. 54
 
Share:
Share:
abstract:
Original paper

Mid-regional pro-adrenomedullin as a predictor of in-hospital mortality in adult patients with COVID-19: a single-centre prospective study

Dmitry Popov
1
,
Ulyana Borovkova
1
,
Mikhail Rybka
1
,
Tatiana Ramnyonok
1
,
Elena Golukhova
1

1.
A.N. Bakulev National Medical Research Center of Cardiovascular Surgery, Moscow, Russia
Anaesthesiol Intensive Ther 2022; 54, 3: 242–246
Online publish date: 2022/09/02
View full text Get citation
 
PlumX metrics:
Background
To determine the predictive value of mid-regional pro-adrenomedullin (MR-proADM) compared to routine clinical and laboratory parameters in patients with COVID-19.

Methods
A total of 135 adult patients hospitalized with COVID-19 were included in a prospective single-centre study. In addition to routine parameters, the levels of MR-proADM in blood plasma were measured on the day of hospitalization. The patients were divided into 2 groups: those who survived and were discharged (n = 115, 85%) and those who did not survive (n = 20, 15%). Data are presented as median and interquartile range.

Results
The non-survivors had a statistically significantly greater age (73.4 [63.5–84.8] vs. 62.2 [50.3–71.4] years, P = 0.001), a lower level of haemoglobin oxygen saturation (91 [87–92] vs. 92 [92–93]%, P < 0.001), lower lymphocyte level (13 [7–30] vs. 21 [15–27]%, P = 0.03), higher lactate dehydrogenase (338 [273–480] vs. 280 [233–383] EU L–1, P = 0.04) and aspartate aminotransferase levels (49 [28–72] vs. 33 [23–47] EU L–1, P = 0.03), a higher National Early Warning (NEWS) score (7 [7– 8] vs. 6 [5–7] points, P < 0.001), and higher procalcitonin (0.16 [0.11–0.32] vs. 0.1 [0.07–0.18] ng mL–1, P = 0.006) and MR-proADM levels (1.288 [0.886–1.847] vs. 0.769 [0.6–0.955] nmol L–1, P < 0.001). MR-proADM had the highest predictive value for death during hospital stay (cut-off: 0.895 nmol L–1, AUC ROC 0.78 [95% CI: 0.66–0.90], sensitivity 75%, specificity 69%, OR 6.58 [95% CI: 2.22–19.51]).

Conclusions
Compared with other indicators, MR-proADM has the highest predictive value for in-hospital mortality in patients with COVID-19.

keywords:

biomarkers, predictors, COVID-19, mortality, pro-adrenomedullin

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.