eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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6/2020
vol. 16
 
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Clinical pharmacology
abstract:
Research letter

Modulation of pro-inflammatory and pro-resolution mediators by γ-linolenic acid: an important element in radioprotection against ionizing radiation

Poorani R
1, 2
,
Anant N. Bhatt
1
,
Undurti N. Das
2, 3

1.
Institute of Nuclear Medicine and Allied Sciences, DRDO, Delhi, India
2.
BioScience Research Centre and Department of Medicine, GVP Hospital and Medical College, Visakhapatnam-530048, India
3.
UND Life Sciences, Battle Ground, WA 98604, USA
Arch Med Sci 2020; 16 (6): 1448–1456
Online publish date: 2020/01/29
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The current study explored the radio-protective property of g-linolenic acid (GLA) in C57BL/6J mice against low linear energy transfer ionizing radiation (IR; X-rays) and its modulatory effect on the production of lipid mediators such as prostaglandin E2 (PGE2), leukotriene E4 and lipoxin A4 (LXA4) in mice plasma. The effect of GLA pre-treatment on radiation induced inflammation was assessed by estimating plasma levels of high mobility group box 1 protein (HMGB1), TMOP/NO and various anti-oxidant enzymes. g-linolenic acid pre-treated mice exposed to lethal IR dose (7.5 Gy) showed a decrease in plasma levels of HMGB1, PGE2 and LXA4 and a fall in TMOP/NO ratio and improvement in anti-oxidant enzymes: catalase, glutathione transferase and glutathione peroxidase compared to IR mice, suggesting that GLA suppresses IR-induced inflammation and restores the pro- vs. anti-oxidant ratio to near normal, which could explain its radioprotective action.
keywords:

g-linolenic acid, ionizing radiation, lipid mediators, inflammation, anti-oxidant enzymes

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