Polish Journal of Pathology
eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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2/2025
vol. 76
 
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abstract:
Case report

Multifocal cutaneous leishmaniasis in a patient treated with golimumab for psoriaticarthritis

Veronica Forte
1
,
Anna Silvia Biamonte
2
,
Massimo Menichini
3
,
Fabrizio Liberati
4
,
Luca Ventura
1

  1. Division of Pathology, San Salvatore Hospital, L’Aquila, Italy
  2. Dermatology Unit, Primary Health Care District, L’Aquila, Italy
  3. Division of Nuclear Medicine, San Salvatore Hospital, L’Aquila, Italy
  4. Division of Pathology, San Camillo de’ Lellis Hospital, Italy
Pol JPathol 2025; 76 (2): 158-162
DOI: https://doi.org/10.5114/pjp.2025.153977
Online publish date: 2025/09/22
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Leishmaniasis is a zoonosis caused by protozoans transmitted by sandflies. Immu­nosuppression is a risk factor for developing leishmaniasis in patients treated with TNF inhibitors for autoimmune diseases. A 65-year-old man with a 14-year histo­ry of psoriatic arthritis in treatment with methotrexate, treated with golimumab during the last 2.5 years, presented ulcerations of the buttocks and upper back. Histopathological findings allowed us to yield the diagnosis of cutaneous leishman­iasis. Therapy was suspended and the patient underwent appropriate treatment. Five cases of leishmaniasis in patients treated with golimumab were reported in literature and ten cases were mentioned in retrospective reviews.
keywords:

Leishmania, psoriasis, psoriatic arthritis, golimumab performance
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