Polish Journal of Pathology

Abstract

4/2024 vol. 75
Review paper

Multinucleate cell angiohistiocytoma: a case series and literature review

  1. Department of Dermatology, Medical University of Warsaw, Warsaw, Poland
Pol J Pathol 2024; 75 (4): 261-267
Online publish date: 2024/12/09
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Confronting perimenopausal women’s knowledge of coronary heart disease with their health behaviours. Controversial role of hormone replacement therapy in the protection of coronary heart disease
Multinucleate cell angiohistiocytoma (MCAH) is a rare benign cutaneous entity. It classically presents as slowly progressive erythematous to violaceous papules on the distal extremities of middle-aged or elderly women. The entity may clinically resemble granuloma annulare, lichen planus, and several cutaneous vascular proliferations. Histologically, MCAH is characterized by vascular proliferation within the upper and mid-dermis, a mild perivascular inflammatory infiltrate, and charac­teristic bizarre-shaped multinucleate cells. To date, less than 200 cases have been reported in the literature. We present five of the best examples diagnosed in our department to further elucidate this peculiar entity for pathological recognition.
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