Multiple gene mutations in patients with type 2 autoimmune pancreatitis and its clinical features

Feng Dong; Qing-quan Chen; Ze-hao Zhuang; Qing-liang He; Feng-qing Wang; Qi-cai Liu; He-kun Liu; Yu Wang

doi:10.5114/ceji.2014.42129

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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1/2014
vol. 39

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abstract:

Multiple gene mutations in patients with type 2 autoimmune pancreatitis and its clinical features

Feng Dong

,

Qing-quan Chen

,

Ze-hao Zhuang

,

Qing-liang He

,

Feng-qing Wang

,

Qi-cai Liu

,

He-kun Liu

,

Yu Wang

(Centr Eur J Immunol 2014; 39 (1): 77-82

DOI: https://doi.org/10.5114/ceji.2014.42129

Online publish date: 2014/04/22

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Background: It is now clear that there are two histological types (type 1 and type 2) of autoimmune pancreatitis (AIP). The histological substance of type 1 AIP is known as lymphoplasmacytic sclerosing pancreatitis (LPSP) or traditional AIP, and type 2 AIP is characterized by distinct histology called idiopathic duct centric pancreatitis (IDCP). Serum IgG4 increase is considered as a marker for type 1 AIP. Far less is known about type 2 and it lacks predicting markers, so it easily leads to missed diagnosis and misdiagnosis.

The aim of this study was to describe multi-gene mutations in patients with type 2 AIP and its clinical features.

Material and methods: Three unrelated patients with type 2 AIP, 10 cases with type 1 AIP, 15 cases with other chronic pancreatitis and 120 healthy individuals were studied. The mutations and polymorphisms of 6 genes involved in chronic pancreatitis or pancreatic cancer — PRSS1, SPINK1, CFTR, MEN1, PKHD1, and mitochondrial DNA – were sequenced. Information of clinical data was collected by personal interview using a structured questionnaire.

Results: Novel mutations were found in the genes encoding for MEN1 (p.546 Ala > The) and PKHD1 (c. 233586 A>G and c. 316713 C>T) from patients with type 2 AIP. What is more, the serum TCR (T cell receptor) level is relatively higher in patients with type 2 AIP than in patients with type 1 AIP and other chronic pancreatitis or normal controls. Weight loss was the major manifestation and no patients had extrapancreatic involvement in type 2 AIP.

Conclusions: Type 2 AIP may occur with multi-gene mutations. For screening purposes, it is more reasonable to evaluate TCR levels in serum.

keywords:

Multiple gene mutations in patients with type 2 autoimmune pancreatitis and its clinical features

Feng Dong , Qing-quan Chen , Ze-hao Zhuang , Qing-liang He , Feng-qing Wang , Qi-cai Liu , He-kun Liu , Yu Wang

autoimmune pancreatitis, type 2, gene mutations, serum TCR

Feng Dong

,

Qing-quan Chen

,

Ze-hao Zhuang

,

Qing-liang He

,

Feng-qing Wang

,

Qi-cai Liu

,

He-kun Liu

,

Yu Wang