Postępy Dermatologii i Alergologii

Full text

3/2026 vol. 43
Review paper

Natural rubber latex allergy: causes, symptoms, and modern diagnostic methods

  1. Individual Specialist Medical Practice, Warsaw, Poland

  2. National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland

Adv Dermatol Allergol 2026; XLIII (3): 233–245

Data publikacji online: 2026/07/19
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  1. Ahmadov F, Ahmadov G, Akbarov R, et al. Investigation of parameters of new MAPD-3NM silicon photomultipliers. J Instrum 2022; 17: C01001.
  2. Jiménez-Carrillo CE, Piña-Ramos KM, Meza-Arrayales C, et al. Latex allergy: Therapeutic options. Allergy J Mex 2022; 69 (Suppl 1): s55-68.
  3. Vajrapatkul A. Modeling Thai concentrated latex sector. Int J Appl Sci Dev 2023; 2: 48-57.
  4. Guerra N, Pegorin G, Boratto M, et al. Biomedical applications of natural rubber latex from the rubber tree Hevea brasiliensis. Mater Sci Eng C 2021; 126: 112126.
  5. Koyuncu A, Elagöz İ, Yava A. Assessing the impact of the COVID-19 pandemic on latex glove usage and latex allergy complaints among nurses. Work 2024; 78: 579-89.
  6. Peixe RG, Sodré MC, Oliveira BB, et al. Active search about latex in injectable drugs for patient’s safety in medical therapy. Rev Bras Farm Hosp Serv Saude 2021; 12: 703.
  7. Cesar M, Borges F, Bilck A, et al. Development and characterization of natural rubber latex and polylactic acid membranes for biomedical application. J Polym Environ 2019; 28: 220-30.
  8. Benjamaa R, Moujanni A, Kaushik N, et al. Euphorbia species latex: phytochemistry and biological activities. Front Plant Sci 2022; 13: 1008881.
  9. Stró¿yk A, Horváth A, Jarocka-Cyrta E, et al. Discrepancy between guidelines and clinical practice in cow’s milk allergy management. Int Arch Allergy Immunol 2022; 183: 931-8.
  10. Bottier C. Biochemical composition of Hevea brasiliensis latex. Adv Bot Res 2020; 93: 201-37.
  11. Della Greca M, Fiorentino A, Monaco P, et al. Effusides I-V: 9,10-dihydrophenanthrene glucosides from Juncus effusus. Phytochem 1995; 40: 533-5.
  12. Lye C, Aun Y, Huat O. Hevea brasiliensis natural rubber structure. Res J Nanoscience Eng 2019; 3: 1-8.
  13. Bae S, Jung S, Choi S, et al. Lipid composition of latex and rubber particles. Molecules 2020; 25: 5110.
  14. Bhadra S, Mohan N, Parikh G, Nair S. Artocarpus heterophyllus latex as alternative rubber source. Polym Test 2019; 79: 106066.
  15. Doroshkevich AS, Zakharova AS, Oksengendler BL, et al. The rectifying contact of hydrated different size YSZ nanoparticles for advanced electronics. Nanomater 2022; 12: 4493.
  16. Merkhatuly N, Iskanderov AN, Abeuova SB, et al. Synthesis of push-pull azulene-based compounds. Eur J Chem 2023; 2023: 36-41.
  17. Rojruthai P, Sakdapipanich J, Wiriyanantawong J, et al. Rubber allergens in sulphur prevulcanized latex. Polymers 2022; 14: 4679.
  18. Cadavid D, Layman R, Nishino T, et al. Guayule latex and Bi2O3 films for medical gloves. Materials 2022; 15: 1184.
  19. Román A, Dibisa O, Pardo G, et al. Ammonia-free natural rubber latex adhesive. SPE Polym 2023; 5: 11-9.
  20. Sukumar T, Varghese J, Bhargavan S, et al. Cytotoxicity of graphene–rubber nanocomposite films. ACS Biomater Sci Eng 2020; 6: 2007-19.
  21. Adekenov SM, Gafurov NM, Turdybekov KM, et al. Chemical modification of the trans,trans-germacranolide stizolicin synthesis, molecular, and crystal structure of 6a-acetoxy-13-methoxy-1,10; 4,5-diepoxy-1,5,7a(H),8,11b(H)-E,E-germacr-8,12-olide. Chem Nat Comp 1991; 27: 690-6.
  22. Giangrieco I, Ricciardi T, Alessandri C, et al. ENEA cross-reacting with latex allergen Hev b 5. Mol Immunol 2019; 112: 347-57.
  23. Đurašinoviæ T, Lopandiæ Z, Protiæ-Rosiæ I, et al. Cross-reactive IgE in ryegrass-, latex-, and kiwifruit-allergic individuals. Int J Mol Sci 2024; 25: 5800.
  24. Gromek W, Ko³dej N, Œwita³a S, et al. Latex–fruit syndrome after 30 years. J Clin Med 2024; 13: 4222.
  25. Čelakovská J, Čermáková E, Vaňková R, et al. Kiwi allergy and latex–fruit syndrome. Food Agric Immunol 2022; 33: 479-97.
  26. Mares-Mejía I, García-Ramírez B, Torres-Larios A, et al. Latex profilin Hev b 8 epitopes. Mol Immunol 2020; 128: 10-21.
  27. Tanaka M, Desai D, Fujiwara Y, et al. Effect of an adjustable hinged carbon fiber operating table on sagittal alignment of the lumbar spine. Appl Sci Switz 2023; 13: 138.
  28. Rutskaya-Moroshan K, Abisheva S, Abisheva A, et al. Clinical characteristics, prognostic factors, and outcomes of COVID-19 in autoimmune rheumatic disease patients: a retrospective case–control study from Astana, Kazakhstan. Med Lith 2024; 60: 1377.
  29. Latka K, Kolodziej W, Pawus D, et al. Performance of successful ambulatory cervical spine surgery: safety, efficacy, and early experiences of first 100 cases in Poland. Br J Neurosurg 2025; 39: 807-12.
  30. Zinabu S, Mohammed A, Ayele G, et al. Latex–fruit syndrome presenting as lower GI bleed. Cureus 2024; 16: e65002.
  31. Gad A, Riad A, Patel J. Latex allergy as COVID-19 hazard. J Oral Diagn Med 2020; 4: 1-2.
  32. Sell AM, Visentainer JEL. Natural rubber latex allergy. In: Allergic diseases. Pereira C (ed.). Rijeka, InTech; 2012; 289-310.
  33. Mwanga H, Baatjies R, Singh T, et al. Work-related allergy and asthma in health workers. Am J Ind Med 2022; 65: 382-95.
  34. Tkach VV, Kushnir MV, de Oliveira SC, et al. The theoretical description for a sucralose electrochemical cathodical determination over a 9-9´-diacridyl-modified electrode. Orbit 2021; 13: 219-22.
  35. Abisheva S, Rutskaya-Moroshan K, Nuranova G, et al. Antimalarial drugs at the intersection of SARS-CoV-2 and rheumatic diseases: what are the potential opportunities? Med Lith 2024; 60: 1171.
  36. Regeda MS, Galii-Lutska VV. Features of changes in some parameters of the cellular and humoral links of the immune system under the conditions of experimental reproduction of allergic alveolitis during immobilization stress. Bull Med Bio Res 2022; 4: 41-8.
  37. Elverişli MF, Yildiz Gülhan P, Mungan D, et al. Latex sensitivity in rubber industry workers. J Occup Environ Med 2023; 65: e378-83.
  38. Wu M, Burdge G, Story J, Webb N. Preventing exposure risks of latex products. Arch Environ Occup Health 2023; 78: 447-53.
  39. Tkach VV, Kushnir MV, de Oliveira SC, et al. Electrochemical determination of sudan dyes and two manner to realize it: a theoretical investigation. Lett Appl NanoBioSci 2020; 9: 1451-8.
  40. Pandey S, Dhungana S, Sharma G. Economics of natural rubber production in Nepal. Arch Agric Environ Sci 2020; 5: 25-32.
  41. Nurgaziyev M, Issilbayeva A, Bersimbaev R, et al. Gut microbiome-immune interactions and their role in rheumatoid arthritis development. PeerJ 2024; 12: e17477.
  42. Waszczuk M, Morozova O, Lhuillier E, et al. Polygenic risk scores and COVID-19 severity. PLoS One 2023; 18: e0282271.
  43. Ferreira M, Vonk J, Baurecht H, et al. Genetic variants associated with allergic disease. PLoS Genet 2020; 16: e1008725.
  44. Hernández C, Casanello P, Harris P, et al. Early origins of allergy and asthma (ARIES). BMC Pediatr 2020; 20: 164.
  45. Grijincu M, Buzan M, Zbîrcea L, et al. Prenatal factors in allergic disease development. Int J Mol Sci 2024; 25: 6359.
  46. Sheikh H, Jha R. Triggered skin sensitivity and contact dermatitis. Cureus 2024; 16: e59486.
  47. Loverre T, Casella R, Miniello A, et al. Latex allergy and component-resolved diagnosis. Endocr Metab Immune Disord Drug Targets 2024; 24: 541-8.
  48. Ozceker D, Haşlak F, Dilek F, et al. Contact sensitization in children with atopic dermatitis. Allergol Immunopathol (Madr) 2019; 47: 47-51.
  49. Tamagawa-Mineoka R, Katoh N. Atopic dermatitis management. Int J Mol Sci 2020; 21: 2671.
  50. Ilderbayev OZ, Zharmakhanova GM, Okassova AK, et al. Comparison of the performance of lipoperoxidation-antioxidant protection system in rats at different periods under immobilization stress effects. Med J Islamic Repub Iran 2021; 35: 113.
  51. Nucera E, Urbani S, Buonomo A, et al. Eosinophilic esophagitis during latex desensitization. J Investig Allergol Clin Immunol 2020; 30: 61-3.
  52. Borovykov V. Evaluation of nanoliposomal forms of retinoids’ efficiency in treatment of acne. Bull Med Bio Res 2025; 7: 69-79.
  53. Romuald DS, Siransy KL, Koffi N, et al. Latex sensitization and asthma progression. Arch Asthma Allergy Immunol 2024; 8: 7-12.
  54. Rhee T, Choi E, Han K, et al. Allergic disease combinations and myocardial infarction. J Allergy Clin Immunol Pract 2021; 9: 872-80.e4.
  55. Silverberg J. Comorbidities of atopic dermatitis. Ann Allergy Asthma Immunol 2019; 123: 144-51.
  56. Thyssen J, Henrohn D, Neary M, et al. Comorbidity burden in adult atopic dermatitis. JEADV Clin Pract 2023; 3: 128-41.
  57. Raulf M. Occupational latex allergy. Curr Opin Allergy Clin Immunol 2020; 20: 112-6.
  58. Malathy PA, Daniel SJ, Venkatesan S, et al. Cutaneous reactions to PPE during COVID-19. Indian J Dermatol 2022; 67: 478.
  59. Stingeni L, Bianchi L, Caroppo E, et al. Italian SIDAPA baseline patch test series. Ital J Dermatol Venereol 2024; 159: 83-104.
  60. Dickel H, Mahler V. Diagnosis of contact allergy in practice. Hautarzt 2020; 71: 182-9.
  61. Han X, Cao M, Zhou B, et al. Magnetic nanoparticle-based IgE detection. Talanta 2020; 219: 121301.
  62. Zhang Z, Cai Z, Hou Y, et al. Capture IgE-ELISA for house dust mite allergy. Mol Med Rep 2019; 19: 3497-504.
  63. Chen Y, He S, Lian H, et al. Microfluidic detection of allergen-specific IgE. Anal Chem 2024; 96: 5625-32.
  64. Gauvreau G, Davis B, Scadding G, et al. Allergen provocation tests in respiratory research. Eur Respir J 2022; 60: 2102782.
  65. Peña-Acevedo Y, Rosado-Ingelmo A, Vargas Porras W, et al. Safety of drug allergy workups. Int Arch Allergy Immunol 2023; 184: 353-65.
  66. Garvey L, Ebo D, Krøigaard M, et al. Drug provocation testing in perioperative allergy. Br J Anaesth 2019; 123: e126-34.
  67. Mahler V. Characteristics of latex allergy sufferers. Karger Compass Dermatol 2019; 7: 29-31.
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