eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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4/2005
vol. 1
 
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abstract:

ORIGINAL PAPER
The association of 25-hydroxyvitamin D levels with secondary hyperparathyroidism in end-stage renal failure patients undergoing regular hemodialysis

Hamid Nasri
,
Azar Baradaran

Arch Med Sci 2005; 1, 4: 236-240
Online publish date: 2005/12/22
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Introduction: To investigate the role of 25-OHD as a marker of nutrition and its association with mineral metabolism and serum parathormone secretion in end-stage renal failure patients undergoing regular hemodialysis (HD), a cross sectional study was carried out on a group of maintenance hemodialysis patients.
Material and methods: Serum 25-hydroxy (25-OH vitamin D) levels, Intact serum PTH (iPTH) and also serum C-reactive protein(CRP), calcium, phosphorus and alkaline phosphatase (ALP) were measured.
Results: In the study, significant differences of serum 25-OH vitamin D between diabetic and non-diabetics of male dialysis patients with more values in nondiabetic HD patients and a significant positive correlation of serum 25-OH vitamin D with BMI and also a near significant inverse correlation of serum
25-OH vitamin D with serum phosphorus were found, also a significant inverse correlation of serum 25-OH VitD with serum calcium was seen, too. Moreover, a weakly significant inverse correlation of serum 25-OH vitamin D with serum iPTH was seen, too. In this study no significant association between serum 25-OH vitamin D with serum albumin, CRP, ALP, dialysis adequacy and ages of the patients, duration and sessions of dialysis were found.
Conclusions: In hemodialysis patients, low serum 25-OHD levels could be a risk factor for secondary hyperparathyroidism. Serum 25-OHD could show the nutritional status of HD patients. In dialysis patients, we suggest that the plasma levels of 25-OHD are maintained around the upper limit of the reference range of sunny countries.
keywords:

25-hydroxy vitamin D, end-stage renal failure, secondary hyperparathyroidism, nutritional status, regular hemodialysis , parathormone

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