Obesity and chronic inflammation crosslinking

Dorota Artemniak-Wojtowicz; Anna Kucharska; Beata Pyrżak

doi:10.5114/ceji.2020.103418

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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4/2020
vol. 45

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abstract:

Review paper

Obesity and chronic inflammation crosslinking

Dorota Artemniak-Wojtowicz

^{1, 2}

,

Anna M. Kucharska

^{1, 2}

,

Beata Pyrżak

^{1, 2}

Department of Paediatrics and Endocrinology, University Clinical Center, Children’s Hospital in Warsaw, Poland

Department of Paediatrics and Endocrinology, Medical University of Warsaw, Poland

Centr Eur J Immunol 2020; 45 (4): 461-468

DOI: https://doi.org/10.5114/ceji.2020.103418

Online publish date: 2021/01/30

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The adipose tissue has been recognized as an active organ involved in numerous metabolic, hormonal and immunological processes. Obesity and associated chronic inflammation leads to many metabolic and autoimmune disorders. The number of cells, their phenotype and distribution in adipose tissue depends on the degree of obesity. Polarization of macrophages towards M1, neutrophils influx to adipose tissue, activation of Th1 and Th17 cells and increased level of proinflammatory cytokines are characteristic for obesity-induced inflammation. Several mechanisms, such as adipocytes’ hypoxia, oxidative stress, endoplasmic reticulum stress, impairment of PPAR receptors, inflammasomes’ activation and activation of TLR are involved into development of chronic obesity-induced inflammation. A better understanding of this processes can provide new treatments for obesity and related disorders.

keywords:

Obesity and chronic inflammation crosslinking

Dorota Artemniak-Wojtowicz 1, 2 , Anna M. Kucharska 1, 2 , Beata Pyrżak 1, 2

obesity, inflammation, children

Dorota Artemniak-Wojtowicz

^{1, 2}

,

Anna M. Kucharska

^{1, 2}

,

Beata Pyrżak

^{1, 2}