eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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3/2005
vol. 1
 
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abstract:

Original paper
C-reactive protein as a predictor of major adverse cardiac events (MACE) after percutaneous coronary intervention?

Leszek Markuszewski
,
Jacek Rysz
,
Marcin Makowski
,
Agnieszka Dębska
,
Robert Pietruszyński

Arch Med Sci 2005; 1, 3: 152-156
Online publish date: 2005/11/10
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Introduction:
Interventional procedures, such as percutaneous coronary intervention (PCI) have significantly improved the prognosis in patients with acute coronary syndromes (ACS). Despite the introduction of new methods the problem of in-stent restenosis in coronary arteries is still being discussed. Therefore finding predictors of this process is crucial. Elevation of C-reactive protein (CRP) can be a useful predictor for restenosis and other major adverse cardiac events (MACE) after PCI.
Material and methods: The studied group consisted of 33 patients (23 males and 10 females; mean age 62.9±8.9) admitted to our Department with myocardial infarction (MI) in whom MACE occurred during 6 months follow-up period. The control group consisted of 33 patients (21 men and 9 women; mean age 61.8±9.8) admitted to hospital for MI, in whom no MACE occurred during 6 months follow-up period. In all patients coronarography was performed and concentrations of CRP were measured, using high sensitivity diagnostic ELISA method (hsCRP). An incorrect level was determined as higher than 6 mg/dl. Patients have been observed during 6 months follow-up. History data were taken from everyone, including information about incidences of MACE or restenosis.
Results: Both studied groups did not differ in parameters describing: sex, age and number of people. In patients with MACE, mean CRP concentration was significantly higher (median 4.8 mg/dl ±; 1.9-11.4) in comparison with the control group (median 2.2; 1.3-4.3); p<0.05.
Conclusion: CRP concentration can be a predictor of MACE after successful PCI.
keywords:

C-reactive protein (CRP), major adverse cardiac events (MACE), percutaneous coronary intervention (PCI), restenosis, inflammation

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