Abstract
4/2013
vol. 30
Original paperGenetic polymorphisms of CYP2D6 oxidation in patients with autoimmune bullous diseases
Postep Derm Alergol 2013; XXX, 4: 211–217
Online publish date: 2013/08/27
Introduction: Bullous skin diseases, which include, among others pemphigoid, pemphigus, and dermatitis herpetiformis are classified as severe autoimmune dermatoses. It has been shown that a pattern of xenobiotic metabolism may play a role in the pathogenesis of autoimmune diseases.
Aim: To estimate whether the CYP2D6 genotype may be considered a predisposing factor in autoimmune bullous diseases induction.
Material and methods: The study included 72 patients with autoimmune bullous diseases: 37 with pemphigoid,
21 with pemphigus, and 14 with dermatitis herpetiformis (DH). The CYP2D6 genotypes were analyzed by the polymerase chain reaction fragment length polymorphism (PCR-RFLP) method.
Results: Relative risk of DH development for particular genotype carriers expressed by odds ratio (OR) was statistically significantly higher for subjects with CYP2D6*1/CYP2D6*4 (OR = 4.2; p = 0.0104) and 2-fold higher for subjects with CYP2D6*4 (OR = 2.3; p = 0.0351).
Conclusions: The results of the present study show that the CYP2D6 oxidation polymorphism cannot be considered a risk factor for development of pemphigoid and pemphigus, however it might have an impact on dermatitis herpetiformis.
Aim: To estimate whether the CYP2D6 genotype may be considered a predisposing factor in autoimmune bullous diseases induction.
Material and methods: The study included 72 patients with autoimmune bullous diseases: 37 with pemphigoid,
21 with pemphigus, and 14 with dermatitis herpetiformis (DH). The CYP2D6 genotypes were analyzed by the polymerase chain reaction fragment length polymorphism (PCR-RFLP) method.
Results: Relative risk of DH development for particular genotype carriers expressed by odds ratio (OR) was statistically significantly higher for subjects with CYP2D6*1/CYP2D6*4 (OR = 4.2; p = 0.0104) and 2-fold higher for subjects with CYP2D6*4 (OR = 2.3; p = 0.0351).
Conclusions: The results of the present study show that the CYP2D6 oxidation polymorphism cannot be considered a risk factor for development of pemphigoid and pemphigus, however it might have an impact on dermatitis herpetiformis.
Keywords
genetic polymorphism, CYP2D6, pemphigoid, pemphigus, dermatitis herpetiformis
Indexed in
Integrated with
