eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
2/2013
vol. 30
 
Share:
Share:
more
 
 
abstract:

Original paper
Serum concentrations of metalloproteinase 2, metalloproteinase 9 and granzyme B in contact eczema patients

Milena Wojciechowska
,
Magdalena Żbikowska-Gotz
,
Rafał Czajkowski
,
Zbigniew Bartuzi

Postep Derm Alergol 2013; XXX, 2: 73–76
Online publish date: 2013/04/12
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction: Contact eczema is a common skin condition with complex etiology, variable clinical presentation and lengthy therapy duration. The mechanism of contact eczema is complex, since it is affected by multiple inflammatory mediators.

Aim: To assess concentrations of metalloproteinase 2 (MMP-2), metalloproteinase 9 (MMP-9) and granzyme B (GzmB) in patients with contact eczema.

Material and methods: Seventy patients with contact eczema and 30 healthy persons as controls were included in the study. In all subjects, MMP-2, MMP-9 and GzmB were determined using ELISA immunoassay. In study group patients, concentrations were assayed in periods of disease exacerbation and remission. Obtained results were analyzed statistically.

Results: Mean MMP-2 and GzmB concentrations were found to be significantly higher in the study group than in the control group. Mean MMP-2, MMP-9 and GzmB levels were also statistically significantly higher during skin lesion relapse compared to contact eczema remission periods.

Conclusions: The presented paper demonstrates that MMP-2, MMP-9 and GzmB are good markers of contact eczema exacerbations.
keywords:

contact eczema, metalloproteinase, granzyme

Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe