eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
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vol. 3

Original paper
Study of relationship between IL-1Ra gene polymorphism and GVHD in HLA – identical sibling allogenic transplants

Mohammad Reza Nooridaloii
Maryam Sobhani
Pantea Izadi
Akbar Fotouhi
Kamran Ali Moghadam
Masoud Iravani
Mohammad Jahani
Babak Bahar
Asadollah Moosavi
Nima Hadiashar
Ardeshir Ghavamzadeh

Arch Med Sci 2007; 3, 1: 52-56
Online publish date: 2007/03/23
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Introduction: The interleukin-1 (IL-1) gene family includes three members (IL-1a, IL-1b and IL-1Ra) that mediate immune and inflammatory responses. Interleukin-1 (IL-1) is an inflammatory cytokine involved in various autoimmune and inflammatory diseases. IL-1 receptor antagonist (IL-1Ra) is the naturally occurring antagonist to IL-1a and IL-1b. A variable number tandem repeat (VNTR) polymorphism in the IL-1Ra gene has been associated with increased IL-1Ra production and affects the severity of aGVHD. Material and methods: Three hundred and fifty pairs (175 HSCT recipients and their donors) were analyzed by VNTR/PCR. Because of haematological disorders all patients were transplanted. All genotypes were screened blind to the clinical outcome of the transplants. GVHD was graded using Glucksberg criteria. Results: The influence of different alleles on incidence of aGVHD was investigated with univariate analysis. None of them showed an association with aGVHD, but possession of allele 2 in donors was associated with less severe aGVHD, although the frequency of allele 2 in our study population was low. However, aGVHD correlated with recipient age, donor age and recipient disease, particularly thalassaemia. Conclusions: No significant correlation was observed between the IL-1Ra polymorphism and incidence of aGVHD. In addition there was a powerful association between diagnosis, particularly thalassaemia, and GVHD (26 out of 30 thalassaemia patients). These findings may help to predict the risk/severity of GVHD, which may contribute to selecting strategies for treatment/prevention in thalassaemia patients.

BMT, cytokine, genotype

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