eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
6/2013
vol. 30
 
Share:
Share:
abstract:

Original paper
Transforming growth factor-β1 in plaque morphea

Aleksandra Dańczak-Pazdrowska
,
Michał J. Kowalczyk
,
Beata Szramka-Pawlak
,
Justyna Gornowicz-Porowska
,
Aleksandra Szewczyk
,
Wojciech Silny
,
Marta Molińska-Glura
,
Anna Olewicz-Gawlik
,
Ryszard Żaba
,
Jakub Pazdrowski
,
Paweł Hrycaj

Postep Derm Alergol 2013; XXX, 6: 337–342
Online publish date: 2013/12/18
View full text Get citation
 
Introduction: Morphea (localized scleroderma) is a rare cutaneous disease characterized by skin fibrosis of unknown pathogenesis. Transforming growth factor-β (TGF-β) is a potent profibrotic factor. The role of TGF-β in morphea remains unclear.

Aim: The goal of this study was to estimate the expression level of TGF-β1 in skin and peripheral blood mononuclear cells as well as the plasma levels of TGF-β1 in plaque morphea (MEP).

Material and methods: The study involved 20 MEP patients. Three control groups were involved: 1 – plasma: 36 healthy volunteers; 2 – PBMC: 47 healthy volunteers; 3 – skin biopsies: 13 samples collected during mastectomy (breast cancer was not skin involved). The analysis of TGF-β1 plasma levels was performed with the use an adequate ELISA kit, while real-time polymerase chain reaction was employed for the expression of TGF-β1 in peripheral blood mononuclear cells (PBMC) and skin.

Results: In our study we have not detected differences in TGF-β 1 expression in PBMC, skin, nor in plasma levels of TGF-β1 between MEP patients and healthy controls, regardless of disease activity and its duration.

Conclusions:: The results of our study contradict the claim of the substantial role of TGF-β1 in the most common morphea subtype – MEP.
keywords:

morphea, scleroderma, transforming growth factor-β, transforming growth factor

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.