eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
5/2013
vol. 30
 
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abstract:

Original papers
Correlation between serum interleukin 31 level and the severity of disease in children with atopic dermatitis

Katarzyna Siniewicz-Luzeńczyk
,
Anna Stańczyk-Przyłuska
,
Krzysztof Zeman

Postep Derm Alergol 2013; XXX, 5: 282–285
Online publish date: 2013/10/30
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Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by intense itch, typical localization and a specific image of skin lesions. Pathogenesis of pruritus in AD is not fully understood, but recent studies emphasize the role of interleukin-31 (IL-31). This relatively recently described cytokine is considered to be a potential mediator inducing pruritus in AD.

Aim: To assess the correlation of serum IL-31 level and the disease severity in children with AD.

Material and methods: Twenty-five children (16 girls and 9 boys) with AD aged from 4 months to 17 years (mean age:

4.2 years) were enrolled in the study. Disease severity in children with AD was assessed using the SCORAD (Severity

SCORing of Atopic Dermatitis) index. Serum IL-31 levels were measured using ELISA with standard kits from EIAab R&D Systems.

Results: Serum IL-31 level was significantly higher in AD children than in healthy children. There was no statistic correlation between serum IL-31 level and the disease severity or itch intensity.

Conclusions: The disease severity and itch intensity do not correlate with serum IL-31 level in children with atopic dermatitis.
keywords:

atopic dermatitis, interleukin 31, SCORAD, pruritus, children

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