eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
2/2020
vol. 37
 
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abstract:
Original paper

Overexpression of cathepsin K and vascular endothelial growth factor in chronic venous ulcerations

Paweł Kolano
1
,
Igor A. Bednarski
2
,
Aleksandra Lesiak
2
,
Małgorzata Skibińska
2
,
Olga Stasikowska-Kanicka
3
,
Marian Danilewicz
3
,
Joanna Narbutt
2

1.
Department of General and Oncological Surgery, Tomaszow Health Centre, Tomaszow Mazowiecki, Poland
2.
Department of Dermatology, Paediatric Dermatology and Oncology, Medical University of Lodz, Lodz, Poland
3.
Department of Pathology, Medical University of Lodz, Lodz, Poland
Adv Dermatol Allergol 2020; XXXVII (2): 234–239
Online publish date: 2020/05/06
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Introduction
Chronic venous disease (CVD) is a disabling condition affecting about 1% to 3% of the general population. Besides varicose veins, CVD can result also in the formation of severe skin lesions, especially venous ulcerations (VU). The exact mechanism of VU is still unknown.

Aim
To evaluate immunoexpression of vascular endothelial growth factor (VEGF) and cathepsin K in healthy individuals and patients with VU.

Material and methods
The study included 12 patients with venous ulcers and 10 healthy individuals who served as controls; both groups were sex- and age-matched. Biopsy samples were obtained from lower leg areas and submitted to histochemical analysis.

Results
There was a significant difference between the study group and the control group in cathepsin K expression (1.007 ±0.3 vs. 0.22 ±0.2, respectively, p < 0.001) and VEGF expression (1.17 ±0.59 vs. 0.27 ±0.19, respectively, p < 0.001). Additionally, the microvessel density (per mm2) differed significantly between the study group and the control group (97.6 ±28.81 vs. 59.32 ±12.71, respectively, p < 0.001). We found no correlation between cathepsin K and microvessel density, and cathepsin K and VEGF in both groups, but there was a significant correlation between microvessel density and VEGF immunoexpression in the study group (r = 0.82, p = 0.002).

Conclusions
Increased immunoexpression of VEGF and cathepsin K suggests that both of these proteins may play a role in VU development.

keywords:

venous ulceration, immunohistochemistry, cathepsin K

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