ISSN: 2451-0629
Archives of Medical Science - Atherosclerotic Diseases
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Official journal of the International Lipid Expert Panel (ILEP)
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1/2020
vol. 5
 
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abstract:
Clinical research

Oxidative stress accelerates the carotid atherosclerosis process in patients with chronic kidney disease

Leila Toualbi Azouaou
1
,
Mounir Adnane
2
,
Abderrezak Khelfi
3
,
Wafa Ballouti
4
,
Medina Arab
5
,
Chahine Toualbi
6
,
Henni Chader
7
,
Ryne Tahae
8
,
Atmane Seba
9

1.
Department of Nephrology, Parnet Hospital Universite, Algiers, Algieria
2.
Department of Biomedicine, Institute of Veterinary Sciences, University of Tiaret, Tiaret, Algeria
3.
Department of Toxicology, Hospital University of Bab el oued, Algiers, Algeria
4.
Department of Biochemistry, Hospital Hussein Dey, Algiers, Algeria
5.
Department of Biochemestry, Hospital University of Mustapha Bacha, Algiers, Algeria
6.
Department of Orthopedic Surgery, Hospital of Bejaia, Bejaia Algeria
7.
Department of Pharmacology, Pastor Institute, Algiers, Algeria
8.
Department of Nephrology, Hospital University of Hussein Dey, Algiers, Algeria
9.
Department of Nephrology, Hospital University of Tizi ouzou, Tizi Ouzou, Algeria
Arch Med Sci Atheroscler Dis 2020; 5: e245–e254
Online publish date: 2020/09/14
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Introduction
The atherosclerosis process is highly accelerated in patients with chronic kidney disease (CKD). Oxidative stress is considered as one of the pro-atherogenic factors involved in accelerating the atherosclerosis process of the carotid artery. The aim of the present study was to determine the relationship between oxidative stress markers and the progression of carotid atherosclerosis in CKD patients.

Material and methods
The study was conducted on 162 patients with CKD and 40 controls, and the disease stage was scored between 2 and 5D. Blood samples were taken and advanced oxidative protein product, myeloperoxidases, malondialdehyde, nitric oxide, glutathione, and oxidised low-density lipoprotein were measured. Furthermore, we studied the correlations between these biomarkers and clinical and para-clinical cardiovascular complications.

Results
The average age of patients was 56.5 years. The oxidative stress markers average ± SD levels in CKD groups compared to the control were as follows: advanced oxidation protein product (61.89 ±1.4 vs. 26.65 ±1.05 µmol/l), myeloperoxidase (59.89 ±1.98 vs. 38.45 ±1.98 UI/ml), malondialdehyde (6.1 ±0.12 vs. 3.26 ±0.03 µmol/l), nitric oxide (65.82 ±1.06 vs. 52.19 ±2.1 µmol/l), glutathione (52.21 ±1.3 vs. 89.4 ±2.6 IU/ml), and oxLDL (15.57 ±1.07 vs. 1.72 ±0.82 µmol/l). While the glutathione level decrease significantly in advanced CKD stage (p < 0.05), the concentrations of all the other biomarkers increased significantly in accordance with CKD score (p < 0.05).

Conclusions
Cardiovascular diseases, mainly atherosclerosis, can be diagnosed indirectly by measuring oxidative stress markers. Furthermore, theses markers can be used to predict the progression of CKD, for better management of the disease.

keywords:

oxidative stress, oxidised low-density lipoprotein, cardiovascular disease, chronic kidney disease

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