PRIDE syndrome with lumbosacral hypertrichosis

Saima Naaz; Hania Khan; Syed Amin; Shriya Kaushik; Shagufta Qadri

doi:10.5114/dr.2022.123989

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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4/2022
vol. 109

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abstract:

Case report

PRIDE syndrome with lumbosacral hypertrichosis

Saima Naaz

¹

,

Hania Qamar Khan

¹

,

Syed Suhail Amin

¹

,

Shriya Kaushik

¹

,

Shagufta Qadri

²

Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India

Dermatol Rev/Przegl Dermatol 2022, 109, 321-326

DOI: https://doi.org/10.5114/dr.2022.123989

Online publish date: 2023/01/16

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Introduction
The PRIDE (Papulopustules and/or paronychia, Regulatory abnormalities of hair growth, Itching, Dryness due to EGFR inhibition) syndrome is a cutaneous adverse effect of EGFR inhibitors.

Case Report
We describe an 80-year-old man, who presented with itchy papules over the suprapubic region and hair growth over the lower back for 1 month. He was diagnosed with squamous cell carcinoma of the lung, and was treated with oral gefitinib 250 mg daily for 4 months. Cutaneous examination revealed generalized xerosis, discrete papules and pustules with overlying yellow crusts over the suprapubic region, and paronychia with dystrophic changes over the right first and third toe nail. Localised hypertrichosis was seen over the back in midline lumbosacral region.

Conclusions
Hair overgrowth such as trichomegaly and hypertrichosis have been described in the PRIDE syndrome. We describe an atypical presentation of the syndrome with lumbosacral hypertrichosis.

keywords:

PRIDE syndrome with lumbosacral hypertrichosis

Saima Naaz 1 , Hania Qamar Khan 1 , Syed Suhail Amin 1 , Shriya Kaushik 1 , Shagufta Qadri 2

hypertrichosis, epidermal growth factor receptor inhibitors, adverse drug reaction, geftinib

Saima Naaz

¹

,

Hania Qamar Khan

¹

,

Syed Suhail Amin

¹

,

Shriya Kaushik

¹

,

Shagufta Qadri

²