Advances in Dermatology and Allergology
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eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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2/2026
vol. 43
 
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abstract:
Original paper

Papulonodular mucinosis with or without systemic lupus erythematosus: a retrospective study

Lu Gan
1
,
Meilin Ding
1
,
Wei Zhang
1
,
Jianfang Sun
1
,
Suying Feng
1
,
Hao Chen
1

  1. Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, China
Adv Dermatol Allergol 2026; XLIII (2): 160–165
DOI: https://doi.org/10.5114/ada.2026.161146
Online publish date: 2026/04/20
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Introduction
Lupus erythematosus-associated skin disease – papulonodular mucinosis (PNM) is characterized by a diffuse deposition of mucin in the dermis. The relationship between PNM and lupus erythematosus and appropriate treatment is crucial for PNM patients.

Aim
To investigate the relationship between systemic lupus erythematosus (SLE) and PNM.

Material and methods
We collected clinicopathological, treatment and follow-up data of 13 patients with PNM of the Chinese Academy of Medical Sciences and Peking Union Medical College from 2004 to 2024. According to the diagnostic criteria for SLE, the patients were divided into two groups: the SLE group and non-SLE group who presented with PNM as major manifestations. The similarities and differences between the two groups were summarised and compared.

Results
Thirteen patients included 8 (61.5%) males and 5 (38.5%) females, who presented with generalized (61.5%) or localized (38.5%) nodules/plaques with a mean onset age of 39.8 years. Among them, 4 (33.3%) cases accorded with the diagnostic criteria for SLE. As to treatment, the SLE group adopted the regimen of systemic prednisolone, hydroxychloroquine and intralesional triamcinolone acetonide. The rest of patients all received systemic prednisolone, together with some other adjuvant therapy. They all gained improvement of varying degree and to date, no SLE symptoms have developed in 11 patients, while 2 patients have developed arthralgia, oral ulcer and alopecia.

Conclusions
Although the clinical presentation varies, the SLE and non-SLE groups of PNM have similar histological features and outcomes, suggesting that these two situations are highly associated.

keywords:

cutaneous lupus, mucinosis, papulonodular mucinosis, systemic lupus erythematosus, treatment

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