eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
2/2020
vol. 37
 
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abstract:
Review paper

Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances

Dominik Samotij
1
,
Bogusław Nedoszytko
2
,
Joanna Bartosińska
3
,
Aleksandra Batycka-Baran
4
,
Rafał Czajkowski
5
,
Iwona T. Dobrucki
6
,
Lawrence W. Dobrucki
6, 7, 8, 9
,
Magdalena Górecka-Sokołowska
10
,
Anna Janaszak-Jasienicka
8, 9
,
Dorota Krasowska
3
,
Leszek Kalinowski
8, 9
,
Marta Macieja-Stawczyk
2
,
Roman J. Nowicki
2
,
Agnieszka Owczarczyk-Saczonek
11
,
Agata Płoska
8, 9
,
Dorota Purzycka-Bohdan
2
,
Adrianna Radulska
8, 9
,
Edyta Reszka
12
,
Anna Siekierzycka
8, 9
,
Andrzej Słomiński
13, 14, 15
,
Radomir Słomiński
16
,
Marta Sobalska-Kwapis
17
,
Dominik Strapagiel
17
,
Aneta Szczerkowska-Dobosz
2
,
Justyna Szczęch
1
,
Michał Żmijewski
18
,
Adam Reich
1

1.
Department of Dermatology, University of Rzeszow, Rzeszow, Poland
2.
Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland
3.
Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland
4.
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland
5.
Department of Dermatology and Venereology, Faculty of Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
6.
Beckman Institute for Advanced Science and Technology, Urbana, IL, USA
7.
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA
8.
Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland
9.
Biobanking and Biomolecular Resources Research Infrastructure, (BBMRI.PL), Gdansk, Poland
10.
Department of Dermatology, Sexually Transmitted Disorders and Immunodermatology, Jurasz University Hospital No. 1, Bydgoszcz, Poland
11.
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland
12.
Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, Lodz, Poland
13.
Department of Dermatology, Birmingham, AL, USA
14.
Comprehensive Cancer Center, Cancer Chemoprevention Program, Birmingham, AL, USA
15.
VA Medical Center, Birmingham, AL, USA
16.
Department of Medicine, Division of Rheumatology, University of Alabama, Birmingham, AL, USA
17.
Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland
18.
Department of Histology, Medical University of Gdansk, Gdansk, Poland
Adv Dermatol Allergol 2020; XXXVII (2): 135–153
Online publish date: 2020/05/05
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Psoriasis is a common, chronic, inflammatory, immune-mediated skin disease affecting about 2% of the world’s population. According to current knowledge, psoriasis is a complex disease that involves various genes and environmental factors, such as stress, injuries, infections and certain medications. The chronic inflammation of psoriasis lesions develops upon epidermal infiltration, activation, and expansion of type 1 and type 17 Th cells. Despite the enormous progress in understanding the mechanisms that cause psoriasis, the target cells and antigens that drive pathogenic T cell responses in psoriatic lesions are still unproven and the autoimmune basis of psoriasis still remains hypothetical. However, since the identification of the Th17 cell subset, the IL-23/Th17 immune axis has been considered a key driver of psoriatic inflammation, which has led to the development of biologic agents that target crucial elements of this pathway. Here we present the current understanding of various aspects in psoriasis pathogenesis.
keywords:

psoriasis, interleukins, autoimmunity, neurogenic inflammation, neoangiogenesis

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