eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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SCImago Journal & Country Rank
3/2020
vol. 37
 
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abstract:
Review paper

Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis

Bogusław Nedoszytko
1
,
Aneta Szczerkowska-Dobosz
1
,
Marta Stawczyk-Macieja
1
,
Agnieszka Owczarczyk-Saczonek
2
,
Adam Reich
3
,
Joanna Bartosińska
4
,
Aleksandra Batycka-Baran
5
,
Rafał Czajkowski
6
,
Iwona T. Dobrucki
7
,
Lawrence W. Dobrucki
7, 8, 9, 10
,
Magdalena Górecka-Sokołowska
6
,
Anna Janaszak-Jasiecka
9
,
Leszek Kalinowski
9, 10, 11
,
Dorota Krasowska
4
,
Dorota Purzycka-Bohdan
1
,
Adrianna Radulska
12
,
Edyta Reszka
13
,
Dominik Samotij
3
,
Marta Sobalska-Kwapis
14
,
Andrzej Słominski
15
,
Radomir Słominski
16
,
Dominik Strapagiel
14
,
Justyna Szczęch
3
,
Michał Żmijewski
17
,
Roman J. Nowicki
1

1.
Chair and Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland
2.
Chair and Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland
3.
Department of Dermatology, University of Rzeszow, Rzeszow, Poland
4.
Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland
5.
Chair and Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland
6.
Chair and Department of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
7.
Beckman Institute for Advanced Science and Technology, Urbana, IL, USA
8.
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL
9.
Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland
10.
Biobanking and Biomolecular Resources Research Infrastructure Poland (BBMRI.PL), Gdansk, Poland
11.
Gdansk University of Technology, Gdansk, Poland
12.
Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland
13.
Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, Lodz, Poland
14.
Biobank Laboratory, University of Lodz, Lodz, Poland
15.
Department of Dermatology University of Alabama at Birmingham, Birmingham, USA
16.
Department of Medicine and Microbiology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA
17.
Department of Histology, Medical University of Gdansk, Gdansk, Poland
Adv Dermatol Allergol 2020; XXXVII (3): 283-298
Online publish date: 2020/07/14
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Psoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors regulating gene expression play a key role. In the “genomic era”, genome-wide association studies together with target genotyping platforms performed in different ethnic populations have found more than 50 genetic susceptible markers associated with the risk of psoriasis which have been identified so far. Up till now, the strongest association with the risk of the disease has been proved for HLA-C*06 gene. The majority of other psoriasis risk SNPs are situated near the genes encoding molecules involved in adaptive and innate immunity, and skin barrier function. Many contemporary studies indicate that the epigenetic changes: histone modification, promoter methylations, long non-coding and micro-RNA hyperexpression are considered as factors contributing to psoriasis pathogenesis as they regulate abnormal keratinocyte differentiation and proliferation, aberrant keratinocytes – inflammatory cells communication, neoangiogenesis and chronic inflammation. The circulating miRNAs detected in the blood may become specific markers in the diagnosis, prognosis and response to the treatment of the disease. The inhibition of expression in selected miRNAs may be a new promising therapy option for patients with psoriasis.
keywords:

psoriasis genetics, genome-wide association studies, epigenetic changes, miRNA

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