eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Journal's reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
5/2020
vol. 37
 
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abstract:
Review paper

Pathogenesis of psoriasis in the “omic” era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis

Aneta Szczerkowska-Dobosz
1
,
Dorota Krasowska
2
,
Joanna Bartosińska
2
,
Marta Stawczyk-Macieja
1
,
Aleksandra Walczak
2
,
Agnieszka Owczarczyk-Saczonek
3
,
Adam Reich
4
,
Aleksandra Batycka-Baran
5
,
Rafał Czajkowski
6
,
Iwona T. Dobrucki
7
,
Lawrence W. Dobrucki
7, 8, 9
,
Magdalena Górecka-Sokołowska
10
,
Anna Janaszak-Jasiecka
8, 9
,
Leszek Kalinowski
7, 8, 9
,
Roman J. Nowicki
1
,
Agata Płoska
8, 9
,
Dorota Purzycka-Bohdan
1
,
Adrianna Radulska
8, 9
,
Edyta Reszka
11
,
Dominik Samotij
4
,
Anna Siekierzycka
8, 9
,
Andrzej T. Slominski
12, 13, 14
,
Radomir M. Slominski
15
,
Marta Sobalska-Kwapis
16
,
Dominik Strapagiel
10
,
Justyna Szczęch
4
,
Michał Żmijewski
17
,
Bogusław Nedoszytko
1

1.
Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland
2.
Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland
3.
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland
4.
Department of Dermatology, University of Rzeszow, Rzeszow, Poland
5.
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland
6.
Department of Dermatology, Sexually Transmitted Disorders and Immunodermatology, Jurasz University Hospital No. 1, Bydgoszcz, Poland
7.
Beckman Institute for Advanced Science and Technology, Urbana, IL, USA
8.
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA
9.
Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland
10.
Biobanking and Biomolecular Resources Research Infrastructure (BBMRI.PL), Gdansk, Poland
11.
Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, Lodz, Poland
12.
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
13.
Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama at Birmingham, Birmingham, AL, USA
14.
Pathology and Laboratory Medicine, VA Medical Center, Birmingham, AL, USA
15.
Department of Medicine and Microbiology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA
16.
Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland
17.
Department of Histology, Medical University of Gdansk, Gdansk, Poland
Adv Dermatol Allergol 2020; XXXVII (5): 625-634
Online publish date: 2020/11/07
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Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis as well as a complex pathogenesis. Genetic and environmental factors trigger the development of the immune-mediated auto-inflammatory response in different sites: skin, bone marrow, entheses and synovial tissues. Studies of the last two decades have changed the view of PsA from a mild, non-progressive arthritis to an inflammatory systemic disease with serious health consequences, not only associated with joint dysfunction, but also with an increased risk of cardiovascular disease and socioeconomic consequences with significantly reduced quality of life. The joint damage starts early in the course of the disease, thus early recognition and treatment with modern biological treatments, which may modify the natural history and slow down progression of this debilitating disease, is essential for the patient long-term outcome.
keywords:

psoriatic arthritis, genetics, immunopathogenesis, classification, treatment

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