eISSN: 1896-9151
ISSN: 1734-1922
Archives of Medical Science
Current issue Archive Manuscripts accepted About the journal Special issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
3/2017
vol. 13
 
Share:
Share:
more
 
 
abstract:
Systematic review/Meta-analysis

Performance of pfHRP2 versus pLDH antigen rapid diagnostic tests for the detection of Plasmodium falciparum: a systematic review and meta-analysis

Bo Li, Zhiqiang Sun, Xiaohan Li, Xiaoxi Li, Han Wang, Weijiao Chen, Peng Chen, Mengran Qiao, Yuanli Mao

Arch Med Sci 2017; 13, 3: 541–549
Online publish date: 2017/04/20
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction: There have been many inconsistent reports about the performance of histidine-rich protein 2 (HRP2) and lactate dehydrogenase (LDH) antigens as rapid diagnostic tests (RDTs) for the diagnosis of past Plasmodium falciparum infections. This meta-analysis was performed to determine the performance of pfHRP2 versus pLDH antigen RDTs in the detection of P. falciparum.

Material and methods: After a systematic review of related studies, Meta-DiSc 1.4 software was used to calculate the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR). Forest plots and summary receiver operating characteristic curve (SROC) analysis were used to summarize the overall test performance.

Results: Fourteen studies which met the inclusion criteria were included in the meta-analysis. The summary performances for pfHRP2- and pLDH-based tests in the diagnosis of P. falciparum infections were as follows: pooled sensitivity, 96.3% (95.8–96.7%) vs. 82.6% (81.7–83.5%); specificity, 86.1% (85.3–86.8%) vs. 95.9% (95.4–96.3%); diagnostic odds ratio (DOR), 243.31 (97.679–606.08) vs. 230.59 (114.98–462.42); and area under ROCs, 0.9822 versus 0.9849 (all p < 0.001).

Conclusions: The two RDTs performed satisfactorily for the diagnosis of P. falciparum, but the pLDH tests had higher specificity, whereas the pfHRP2 tests had better sensitivity. The pfHRP2 tests had slightly greater accuracy compared to the pLDH tests. A combination of both antigens might be a more reliable approach for the diagnosis of malaria.
keywords:

histidine-rich protein 2, lactate dehydrogenase, rapid diagnostic tests, Plasmodium falciparum

FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe